The George Institute For Global Health
Global
United Kingdom
India
China
Australia

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)

Project status: 
Active
Start date: 
01/2012
Fact sheet

ENCHANTED is an international randomised controlled trial to establish the effects of low–dose serine protease, rtPA and the effects of early intensive blood pressure lowering in patients with acute ischaemic stroke. It is a global public health study into acute ischaemic stroke aiming to improve the treatment of stroke which affects 15 million people worldwide, causing premature death and disability. Participating countries and regions include Australia, China (mainland), United Kingdom, South Korea, Chile, Vietnam, Taiwan, Brazil, Singapore, Italy, Spain, Norway, Colombia, Hong Kong and Thailand.

The issue

Ischaemic stroke caused by acute occlusion of an artery leading to immediate reduction in blood flow within the corresponding cerebrovascular territory, causes 9% of all deaths around the world, and is associated with a very high health-care and socioeconomic costs. Early spontaneous re-canalisation may occur from the endogenous release of rtPA, a serine protease of the fibrinolytic system. However, for most patients, this natural physiological function is inadequate to avoid the outcome of infarcted cerebral tissue from the occluded vessel.  rtPA is the only approved treatment of acute ischaemic stroke despite increased risk of symptomatic intracerebral haemorrhage (sICH).

Recent studies suggest that low-dose of rtPA is an effective treatment and may have a reduced risk of sICH but there is lack of reliable randomised evidence to support it.

Methods

ENCHANTED is an independent, investigator initiated, international collaborative, quasi-factorial randomised controlled trial.

Mor​e information

ENCHANTED study

New England Journal of Medicine