@article{16186,
  author = {Grobbee D. and Czernichow S. and Julia C. and Henegar A. and Bitu J. and Hu F. and Hercberg S. and Kengne Andre and Fezeu L.},
  title = {Obesity is associated with higher risk of intensive care unit admission and death in influenza A (H1N1) patients: a systematic review and meta-analysis},
  abstract = {<p>
The aim of this study was to assess the association between obesity and the risk of intensive care unit (ICU) admission and death among patients hospitalized for influenza A (H1N1) viral infection. A systematic review of the Medline and Cochrane databases using 'obesity', 'hospitalization', 'influenza A viral infection', various synonyms, and reference lists of retrieved articles from January 2009 to January 2010. Studies comparing the prevalence of obesity among patients with confirmed infection for influenza A virus and who were either hospitalized or admitted to ICU/died were included. A total of 3059 subjects from six cross-sectional studies, who were hospitalized for influenza A (H1N1) viral infection, were included in this meta-analysis. Severely obese H1N1 patients (body mass index &gt;/= 40 kg m(-2), n = 804) were as twice as likely to be admitted to ICU or die (odds ration: 2.01, 95% confidence interval: 1.29-3.14, P &lt; 0.002) compared with H1N1 patients who were not severely obese. Having a body mass index &gt;/= 30 kg m(-2) was similarly associated with a more than twofold increased risk of ICU admission or death although this did not reach statistical significance (2.14, 0.92-4.99, P &lt; 0.07). This meta-analysis supports the view that obesity is associated with higher risks of ICU admission or death in patients with influenza A (H1N1) infection. Therefore, morbid obese patients should be monitored more intensively when hospitalized.
</p>
},
  year = {2011},
  journal = {Obesity Reviews},
  volume = {12},
  edition = {2011/04/05},
  number = {8},
  pages = {653-9},
  isbn = {1467-789X (Electronic)1467-7881 (Linking)},
  note = {Fezeu, LJulia, CHenegar, ABitu, JHu, F BGrobbee, D EKengne, A-PHercberg, SCzernichow, SMeta-AnalysisReviewEnglandObes Rev. 2011 Aug;12(8):653-9. doi: 10.1111/j.1467-789X.2011.00864.x. Epub 2011 Apr 4.},
  language = {eng},
}