@article{16275,
  author = {Lindley Richard and Mitchell P. and De Silva D. and Woon F. and Manzano J. and Liu E. and Chang H. and Chen C. and Wang J. and Kingwell B. and Cameron J. and Wong T. and Wong M.},
  title = {The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients},
  abstract = {<p>
Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.Journal of Human Hypertension advance online publication, 6 October 2011; doi:10.1038/jhh.2011.88.
</p>
},
  year = {2011},
  journal = {Journal of Human Hypertension},
  edition = {2011/10/07},
  month = {229320469059},
  isbn = {1476-5527 (Electronic)0950-9240 (Linking)},
  note = {De Silva, D AWoon, F-PManzano, J J FLiu, E YChang, H-MChen, CWang, J JMitchell, PKingwell, B ACameron, J DLindley, R IWong, T YWong, M-CJ Hum Hypertens. 2011 Oct 6. doi: 10.1038/jhh.2011.88.},
  language = {Eng},
}