@article{16409,
  author = {Heerspink H. and Gerstein H. and Turnbull Fiona and Diener H. and Marzona I. and Nissen S and de Zeeuw D. and Fox K. and Dagenais G. and Brenner B. and Pfeffer M. and Renin Angiotension System Modulator Meta-Analysis Investigators and McAlister F. and Teo K. and Marre M. and Yusuf S. and Simoons M. and Jung H. and Lowering B. and Kober L. and Sacco R. and Chalmers J. and Neal Bruce and Macmahon S},
  title = {Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are beneficial in normotensive atherosclerotic patients: a collaborative meta-analysis of randomized trials},
  abstract = {<p>
AIMS: It is unclear whether angiotensin-converting enzyme inhibitors (ACE-I) or angiotensin receptor blockers (ARB) are beneficial in individuals with, or at increased risk for, atherosclerotic vascular disease who are normotensive. METHODS AND RESULTS: Two investigators independently searched MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from 1980 to 2011, bibliographies, and contacted primary study authors for randomized placebo-controlled outcome trials evaluating ACE-I or ARB which enrolled at least 1000 patients with, or at increased risk for, atherosclerotic vascular disease and followed them for at least 12 months. We approached all eligible trials to obtain data stratified by baseline systolic pressures. We pooled data from 13 trials of 80 594 patients; outcomes included 9043 all-cause deaths, 5674 cardiovascular deaths, 3106 myocardial infarctions, and 4452 strokes. Angiotensin-converting enzyme inhibitors or ARB reduced the composite primary outcome of cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke by 11% (95% confidence interval 7-15%), with no variation in efficacy across baseline systolic blood pressure strata. In patients with baseline systolic pressure &lt;130 mmHg, ACE-I or ARB reduced the composite primary outcome by 16% (10-23%) and all-cause mortality by 11% (4-18%)-this benefit was consistent across all subgroups examined including those without systolic heart failure (OR: 0.81, 95% CI: 0.75-0.88) and those without diabetes (OR: 0.79, 95% CI: 0.70-0.89). CONCLUSION: Angiotensin-converting enzyme inhibitors or ARB are beneficial in patients with, or at increased risk for, atherosclerotic disease even if their systolic pressure is &lt;130 mmHg before treatment.
</p>
},
  year = {2012},
  journal = {European Heart Journal},
  volume = {33},
  edition = {2011/11/02},
  number = {4},
  pages = {505-14},
  isbn = {1522-9645 (Electronic)0195-668X (Linking)},
  note = {McAlister, Finlay ARenin Angiotension System Modulator Meta-Analysis InvestigatorsCanadian Institutes of Health Research/CanadaMeta-AnalysisResearch Support, Non-U.S. Gov'tEnglandEuropean heart journalEur Heart J. 2012 Feb;33(4):505-14. Epub 2011 Oct 31.},
  language = {eng},
}