@article{16785,
  author = {Muntner P. and Mann D. and Wildman R. and Fuster V. and Woodward Mark and Shimbo D.},
  title = {Projected impact of polypill use among US adults: Medication use, cardiovascular risk reduction, and side effects},
  abstract = {<p>
BACKGROUND: Polypills, which include multiple medications for reducing cardiovascular disease (CVD) risk in a single pill, have been proposed for population-wide use. The number of US adults eligible for polypills and potential benefits are unknown. METHODS: The National Health and Nutrition Examination Survey 2003-2004 and 2007-2008 were analyzed to estimate treatment rates for medications proposed for inclusion in polypills (aspirin, statin, an angiotensin-converting enzyme [ACE] inhibitor, and a thiazide-type diuretic for those without and a beta-blocker for those with a history of myocardial infarction) among US adults. The number of coronary heart disease (CHD) and stroke events potentially prevented through polypill use was projected by published meta-analyses and 3 large population-based cohort studies. Two polypill eligibility criteria were analyzed: (1) US adults &gt;/=55 years and (2) US adults with a history of CVD. RESULTS: There are 67.6 million US adults &gt;/=55 years and 15.4 million US adults with a history of CVD and, thus, eligible for polypills using the 2 outlined criteria. In 2007 to 2008, 37.3% of US adults &gt;/=55 years and 57.0% of those with a history of CVD were taking statins. Use of other polypill medications was also low. Polypill use by US adults aged &gt;/=55 years is projected to potentially prevent 3.2 million CHD events and 1.7 million strokes over 10 years. Among those with a history of CVD, the potential to prevent of 0.9 million CHD events and 0.5 million strokes is projected. CONCLUSIONS: Polypills have the potential to lower CVD incidence substantially among US adults.
</p>
},
  year = {2011},
  journal = {American Heart Journal},
  volume = {161},
  edition = {2011/04/09},
  number = {4},
  pages = {719-25},
  month = {78036400918},
  isbn = {1097-6744 (Electronic)0002-8703 (Linking)},
  note = {Muntner, PaulMann, DevinWildman, Rachel PShimbo, DaichiFuster, ValentinWoodward, MarkUnited StatesAmerican heart journalAm Heart J. 2011 Apr;161(4):719-25.},
  language = {eng},
}