@article{21965,
  author = {Wu J. and Song X. and Yang J. and Mozaffarian D. and Akintoye E. and Hou T. and Hammock B.},
  title = {Effect of Fish Oil on Monoepoxides Derived from Fatty Acids during Cardiac Surgery},
  abstract = {<p>
Objective Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Methods and Results 479 patients undergoing cardiac surgery in three countries were randomized to peri-operative fish oil (EPA+DHA; 8-10g over 2-5 days pre-operatively then 2 g/d post-operatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFA were measured 2 days post-operatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined from enrollment to post-op day 2, with declines ranging from 37 to 63% (P&lt;0.05 each). Compared to placebo at post-op day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P<!--=0.004). n-3 PUFA supplementation did not significantly alter n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at post-op day-2 (p<0.001). Conclusions Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in post-operative n-3 MEFAs, but not n-6 MEFAs; and levels of increase related to circulating n-3 PUFA precursors.-->
</p>
},
  year = {2016},
  journal = {Journal of Lipid Research},
  volume = {57},
  edition = {2016/01/11},
  number = {3},
  pages = {492-8},
  month = {93562401117},
  isbn = {0022-2275 (Electronic)<br/>0022-2275 (Linking)},
  note = {Akintoye, Emmanuel<br/>Wu, Jason H Y<br/>Hou, Tao<br/>Song, Xiaoling<br/>Yang, Jun<br/>Hammock, Bruce<br/>Mozaffarian, Dariush<br/>J Lipid Res. 2016 Jan 9. pii: jlr.P062398.},
  language = {Eng},
}