@article{22901,
  keywords = {Adult, Female, Humans, Male, Middle Aged, Cardiovascular Diseases, biomarkers, Renal Insufficiency, Chronic, Dietary Supplements, C-Reactive Protein, Endothelium, Vascular, Interleukin-6, Pulse Wave Analysis, Vascular Stiffness, Vasodilation, Vitamin D, Vitamins},
  author = {Kumar Vinod and Jha V. and Kumar Vivek and Yadav Ashok and Gupta Krishan and Billot Laurent and Lal Anupam and Singhal Manphool and Banerjee Debasish},
  title = {A Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.},
  abstract = {<p>Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%;<0.001). Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels. Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascular function. This study is registered with the Clinical Trials Registry of India (no.: CTRI/2013/05/003648).</p>},
  year = {2017},
  journal = {J Am Soc Nephrol},
  volume = {28},
  pages = {3100-3108},
  issn = {1533-3450},
  doi = {10.1681/ASN.2017010003},
  language = {eng},
}