02742nas a2200373   4500000000100000008004100001653001100042653001100053653000900064653002800073653001800101653002200119653001500141653001300156653002100169653001800190653001800208653001900226653001700245653000900262100001900271700001800290700001300308700001400321700001800335700001600353700001800369245012400387250001500511300001000526490000700536520177900543020004602322       2012                            d10aFemale10aHumans10aMale10aCross-Sectional Studies10aEnergy Intake10aEnteral Nutrition10aAdolescent10aChildren10aChild, Preschool10aAnthropometry10aLinear Models10aCerebral Palsy10aMalnutrition10aRest1 aBarzi Federica1 aArrowsmith F.1 aAllen J.1 aGaskin K.1 aSomerville H.1 aBirdsall J.1 aO'Loughlin E.00aNutritional rehabilitation increases the resting energy expenditure of malnourished children with severe cerebral palsy  a2012/01/10  a170-50 v543 a<p>
AIM: The aim of this study was to measure resting energy expenditure (REE) and energy intake in children with quadriplegic cerebral palsy (CP), to relate these to anthropometric measurements, and to determine the influence of nutritional rehabilitation on REE. METHODS: Fifty-six children (20 females, 36 males; age range 3y 11mo-18y; mean age 10y; SD 3y 11mo) with CP (Gross Motor Function Classification System level V) participated in this cross-sectional study. Children were excluded if they had a known metabolic disorder, genetic syndrome, or chromosomal abnormality. Thirty-three of the children were tube fed and 23 were fed orally. A comparison group comprised 111 (42 females, 69 males) healthy children who had undergone anthropometric and REE measurements and were of similar age to the children with CP (4-19y). REE was measured by indirect calorimetry and energy intake was determined from weighed food records. RESULTS: The REE in the children with CP was low (79.5%) compared with that predicted and highly variable (SD 38.4%). Fat-free mass was the strongest predictor of REE, accounting for 27% of the variation. Energy intake as a percentage of REE in was greatly overestimated in oral-fed children with CP (293%). In a subset of children with CP (n=14), an increased energy intake by gastrostomy tube feeding resulted in an increase in REE from 70.0% to 101.9% of that predicted. INTERPRETATION: The REE of children with CP is low and variable and is not strongly related to any one anthropometric measurement. Food records in oral-fed children with CP are of little value owing to their inaccuracy. This study provided support for the hypothesis that the low REE found in malnourished children with CP is partly due to a low energy intake.
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