02126nas a2200181   4500000000100000008004100001100001800042700001800060700001300078700001700091700001300108245018700121250001500308300001200323490000700335520155600342020004601898       2012                            d1 aCzernichow S.1 aStamatakis E.1 aHamer M.1 aKengne Andre1 aBatty G.00aAssociation of C-Reactive Protein With Cardiovascular Disease Mortality According to Diabetes Status: Pooled analyses of 25,979 participants from four U.K. prospective cohort studies  a2012/01/03  a396-4030 v353 a<p>
OBJECTIVE C-reactive protein (CRP) is associated with the risk of cardiovascular disease (CVD); whether the effects are modified by diabetes status still is unclear. This study investigated these issues and assessed the added value of CRP to predictions. RESEARCH DESIGN AND METHODS Participants were drawn from representative samples of adults living in England and Scotland. Cox proportional hazards regression models were used to relate baseline plasma CRP with all-cause and CVD mortality during follow-up in men and women with and without diabetes. The added value of CRP to the predictions was assessed through c-statistic comparison and relative integrated discrimination improvement. RESULTS A total of 25,979 participants (4.9% with diabetes) were followed for a median of 93 months, during which period there were 2,767 deaths (957 from CVD). CRP (per SD log(e)) was associated with a 53% (95% CI 43-64) and 43% (38-49) higher risk of cardiovascular and all-cause mortality, respectively. These associations were log linear and did not differ according to diabetes status (both P &gt;/= 0.08 for interaction), sex, and other risk factors. Adding CRP to conventional risk factors improved predictions overall and separately by diabetes status but not for CVD mortality, although such improvements only were marginal based on several discrimination statistics. CONCLUSIONS The association between CRP and CVD was similar across diabetes status, and the effects are broadly similar across levels of other conventional risk factors.
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