02058nas a2200253   4500000000100000008004100001100002200042700001700064700001900081700001500100700001400115700001300129700001400142700001600156700001900172700001500191700001800206245014700224250001500371300001100386490000700397520135400404020004601758       2010                            d1 ade Galan Bastiaan1 aKengne Andre1 aZoungas Sophia1 aPoulter N.1 aPillai A.1 aMarre M.1 aHarrap S.1 aChalmers J.1 aBillot Laurent1 aNeal Bruce1 aPatel Anushka00aThe efficacy of lowering glycated haemoglobin with a gliclazide modified release-based intensive glucose lowering regimen in the ADVANCE trial  a2010/06/15  a126-330 v893 a<p>
The aim of these analyses was to examine the efficacy of the intensive gliclazide MR-based glucose lowering regimen used in the ADVANCE trial in lowering the level of glycated haemoglobin (HbA1c). All 11,140 randomised patients were included in analyses of treatment efficacy. Treatment efficacy was also examined in subgroups defined by baseline characteristics and treatments. At the end of 5 years follow-up, the mean HbA1c was reduced from 7.5% at baseline to 6.5% in those on intensive glucose control and to 7.3% in those on standard glucose control. With intensive glucose lowering greater proportions achieved HbA1c levels of &lt; or =7.0%, &lt; or =6.5% and &lt; or =6.0%. With intensive glucose lowering substantial reductions in HbA1c were observed across subgroups defined by baseline age, sex, duration of diabetes, BMI, HbA1c or treatment regimen (p&lt;0.0001). The main independent predictors of reduction in HbA1c during follow-up were baseline HbA1c, duration of diabetes and BMI. There was no weight gain in the intensive glucose control group and severe hypoglycaemia was uncommon, though more frequent than in the standard control group. Intensive glucose control with a gliclazide MR-based regimen was well tolerated and consistently effective in lowering HbA1c across a broad range of patient with type 2 diabetes.
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