02329nas a2200193   4500000000100000008004100001100001400042700001300056700001500069700001500084700002000099700001400119245009100133250001500224300001100239490000700250520183200257020004602089       2011                            d1 aCass Alan1 aWhite S.1 aDunstan D.1 aChadban S.1 aPolkinghorne K.1 aAtkins R.00aPhysical inactivity and chronic kidney disease in Australian adults: the AusDiab study  a2009/11/27  a104-120 v213 a<p>
BACKGROUND AND AIMS: Physical inactivity is associated with cardiovascular risk however its relationship to chronic kidney disease is largely unknown. We examined the association between leisure-time physical activity and risk of chronic kidney disease in a prospective, population-based cohort of Australians aged &gt;/= 25 years (AusDiab). METHODS AND RESULTS: The baseline sample included 10,966 adults (4951 males and 6015 females). From this sample, 6318 participants with complete baseline and 5-year follow-up urinalysis and serum creatinine measurements formed the study population for longitudinal analysis. Self-reported leisure-time physical activity was measured using a validated, interviewer-administered questionnaire. Compared with sufficiently active individuals (&gt;/= 150 min physical activity per week), those who were inactive (0 min/week) were more likely to have albuminuria at baseline (multivariate-adjusted OR=1.34, 95% CI 1.10-1.63). Inactivity (versus sufficient physical activity) was associated with increased age- and sex-adjusted odds of an estimated glomerular filtration rate &lt;3rd percentile (OR=1.30, 95% CI 1.02-1.65), although this was not significant after multivariate adjustment (OR=1.17, 95% CI 0.91-1.50). Obese, inactive individuals were significantly more likely to have albuminuria at baseline (multivariate-adjusted OR=1.74, 95% CI 1.35-2.25), compared with sufficiently active, non-obese individuals. Baseline physical activity status was not significantly associated with longitudinal outcomes. CONCLUSIONS: Physical inactivity is cross-sectionally associated with albuminuria prevalence, particularly when combined with obesity. Future studies are needed to determine whether this association is causal and the importance of physical activity in CKD prevention.
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