02391nas a2200265   4500000000100000008004100001100001500042700001300057700001100070700001300081700001800094700001500112700001300127700001500140700001400155700001600169700001500185700001800200245010300218250001500321300001100336490000700347520172500354020004602079       2010                            d1 aGrobbee D.1 aStolk R.1 aLee C.1 aAdler A.1 aWoodward Mark1 aPoulter N.1 aMarre M.1 aBeulens J.1 aHarrap S.1 aChalmers J.1 aNeal Bruce1 aPatel Anushka00aAssociation between alcohol consumption and diabetic retinopathy and visual acuity-the AdRem Study  a2010/09/22  a1130-70 v273 a<p>
AIMS: We investigated the association between alcohol consumption and diabetic retinopathy and deterioration of visual acuity in individuals with Type 2 diabetes. METHODS: We conducted a cohort analysis of 1239 participants with Type 2 diabetes aged 55-81 years enrolled in the AdRem study, a sub-study of the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial. Current and past consumption of wine, spirits and beer was measured by self-report. Moderate and heavy alcohol consumption was defined as 1-14 and &gt;14 drinks/week, respectively. Diabetic retinopathy, measured by mydriatic stereoscopic seven-field retinal photography, was defined by a 2-step progression in the Early Treatment of Diabetic Retinopathy Study (ETDRS) score or the presence of any retinal vascular lesions. Deterioration of visual acuity was defined by a decrease of two lines in best vision in either eye, measured corrected, or through a pinhole using a Snellen chart. RESULTS: In a mean follow-up of 5.5 years, we identified 182 participants with a 2-step progression in the ETDRS score, 640 participants with the presence of any retinal vascular lesions and 693 participants with a deterioration of visual acuity. Current moderate consumption of alcohol, compared with no current consumption, was not associated with presence or progression of diabetic retinopathy; however, it was associated with higher risk of deterioration of visual acuity (multivariable-adjusted OR 1.83; 95% CI 1.34-2.48; P&lt;0.001). CONCLUSIONS: Alcohol consumption is associated with increased risk of deterioration of visual acuity, but not with retinopathy in individuals with Type 2 diabetes.
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