02050nas a2200277   4500000000100000008004100001100001600042700001400058700001300072700001300085700001300098700002700111700001400138700001100152700001400163700001300177700001500190700001500205700001000220245015600230250001500386300001000401490000800411520130700419020004601726       2010                            d1 aGraubard B.1 aFraser D.1 aBrock K.1 aHuang W.1 aTseng M.1 aStolzenberg-Solomon R.1 aPeters U.1 aAhn J.1 aPurdue M.1 aMason R.1 aMcCarty C.1 aZiegler R.1 aKe L.00aLow vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women  a2010/04/20  a462-60 v1213 a<p>
The aim of this study was to investigate modifiable predictors of vitamin D status in healthy individuals, aged 55-74, and living across the USA. Vitamin D status [serum 25-hydroxyvitamin D (25(OH)D)] was measured along with age and season at blood collection, demographics, anthropometry, physical activity (PA), diet, and other lifestyle factors in 1357 male and 1264 female controls selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Multivariate linear and logistic regression analyses were used to identify associations with vitamin D status. Three%, 29% and 79% of the population had serum 25(OH)D levels&lt;25, &lt;50 and &lt;80 nmol/L, respectively. The major modifiable predictors of low vitamin D status were low vitamin D dietary and supplement intake, body mass index (BMI) &gt;30 kg/m2, physical inactivity (PA) and low milk and calcium supplement intake. In men, 25(OH)D was determined more by milk intake on cereal and in women, by vitamin D and calcium supplement and menopausal hormone therapy (MHT) use. Thus targeting an increase in vigorous activity and vitamin D and calcium intake and decreasing obesity could be public health interventions independent of sun exposure to improve vitamin D status in middle-aged Americans.
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