02533nas a2200289   4500000000100000008004100001100001700042700001200059700001600071700002000087700001600107700001500123700001400138700001700152700001700169700001400186700001400200700005200214700001600266700001500282245011400297250001500411300001000426490000800436520175300444020004602197       2010                            d1 aFinfer Simon1 aHowe B.1 aMorrison S.1 aBellomo Rinaldo1 aSullivan S.1 aEllwood D.1 aKnight M.1 aMcDonnell N.1 aMcLintock C.1 aMorgan T.1 aNguyen N.1 aANZICS Clinical Trial Group (Writing Committee)1 aMcArthur C.1 aSeppelt I.00aCritical illness due to 2009 A/H1N1 influenza in pregnant and postpartum women: population based cohort study  a2010/03/20  ac12790 v3403 a<p>
OBJECTIVE: To describe the epidemiology of 2009 A/H1N1 influenza in critically ill pregnant women. DESIGN: Population based cohort study. SETTING: All intensive care units in Australia and New Zealand. PARTICIPANTS: All women with 2009 H1N1 influenza who were pregnant or recently post partum and admitted to an intensive care unit in Australia or New Zealand between 1 June and 31 August 2009. MAIN OUTCOME MEASURES: Maternal and neonatal mortality and morbidity. RESULTS: 64 pregnant or postpartum women admitted to an intensive care unit had confirmed 2009 H1N1 influenza. Compared with non-pregnant women of childbearing age, pregnant or postpartum women with 2009 H1N1 influenza were at increased risk of admission to an intensive care unit (relative risk 7.4, 95% confidence interval 5.5 to 10.0). This risk was 13-fold greater (13.2, 9.6 to 18.3) for women at 20 or more weeks' gestation. At the time of admission to an intensive care unit, 22 women (34%) were post partum and two had miscarried. 14 women (22%) gave birth during their stay in intensive care and 26 (41%) were discharged from an intensive care unit with ongoing pregnancy. All subsequently delivered. 44 women (69%) were mechanically ventilated. Of these, nine (14%) were treated with extracorporeal membrane oxygenation. Seven women (11%) died. Of 60 births after 20 weeks' gestation, four were stillbirths and three were infant deaths. 22 (39%) of the liveborn babies were preterm and 32 (57%) were admitted to a neonatal intensive care unit. Of 20 babies tested, two were positive for the 2009 H1N1 virus. CONCLUSIONS: Pregnancy is a risk factor for critical illness related to 2009 H1N1 influenza, which causes maternal and neonatal morbidity and mortality.
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