01917nas a2200241   4500000000100000008004100001653002400042653001200066100001600078700001200094700001600106700001600122700001400138700001400152700001700166700001400183700001100197245009200208300003500300490000700335050000600342520132700348       2005                            d10aPeer Reviewed Paper10aChecked1 aElkins Mark1 aLane T.1 aGoldberg H.1 aPagliuso J.1 aGarske L.1 aHector E.1 aMarchetto L.1 aAlison J.1 aBye P.00aEffect of airway clearance techniques on the efficacy of the sputum induction procedure  a904-908. [Impact Factor 5.349]0 v26  aN3 a<p>
Sputum induction is used in the early identification of tuberculosis (TB) and pneumocystis infections of the lung. Although manual physiotherapy techniques to clear the airways are often incorporated in the sputum induction procedure, their efficacy in this setting is unknown. This randomised, crossover trial enrolled adults referred for sputum induction for suspected TB and pneumocystis infections of the lung. All participants underwent two sputum induction procedures, inhaling 3% saline via ultrasonic nebuliser. During one randomly allocated procedure, airway clearance techniques (chest wall percussion, vibration, huffing) were incorporated. In total, 59 participants completed the trial. The airway clearance techniques had no significant effect on how the test was tolerated, the volume expectorated or the quality of the sample obtained (assessed by the presence of alveolar macrophages). The techniques did not significantly affect how often the test identified a suspected organism, nor the sensitivity or specificity of sputum induction. In conclusion, the study was unable to demonstrate any effect of airway clearance techniques on the sputum induction procedure. The results provide some justification for not including airway clearance techniques as part of the sputum induction procedure.
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