02131nas a2200217   4500000000100000008004100001100001800042700001900060700001800079700001600097700001300113700001500126700001400141700001600155700001500171700001800186245012100204250001500325520152700340020004601867       2013                            d1 aWoodward Mark1 aZoungas Sophia1 aHillis Graham1 aBlomster J.1 aMarre M.1 aPoulter N.1 aHarrap S.1 aChalmers J.1 aChow Clara1 aPatel Anushka00aThe Influence Of Physical Activity On Vascular Complications And Mortality In Patients With Type 2 Diabetes Mellitus  a2013/05/173 a<p>
AIMS: There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. MATERIALS AND METHODS: From the 11,140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality. RESULTS: Forty-six percent of participants reported undertaking moderate to vigorous physical activity for &gt;15 minutes at least once in the previous week. During a median of 5 years of follow up, 1,031 patients died, 1,147 experienced a major cardiovascular event and 1,136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events (HR 0.78, 95% CI 0.69-0.88, p &lt; 0.0001), microvascular events (HR 0.85, 95% CI 0.76-0.96, p0.010) and all-cause mortality (HR 0.83, 95% CI 0.73-0.94, p0.0044). CONCLUSIONS: Moderate to vigorous, but not mild, physical activity is associated with a reduced incidence of cardiovascular events, microvascular complications and all-cause mortality in patients with type 2 diabetes.
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