01846nas a2200181   4500000000100000008004100001100001500042700001400057700001600071700001500087700001400102700001500116700002100131245015100152250001500303520129700318020004901615       2013                            d1 aLatimer J.1 aGrotle M.1 aFerreira P.1 aHerbert R.1 aOstelo R.1 aBarrett B.1 aFerreira Manuela00aThe smallest worthwhile effect of nonsteroidal anti-inflammatory drugs and physiotherapy for chronic low back pain: a benefit-harm trade-off study  a2013/09/123 a<p>
OBJECTIVE: The aim of this study was to determine the smallest worthwhile effects of two treatments for nonspecific low back pain (LBP). STUDY DESIGN AND SETTING: The benefit-harm trade-off method was used to estimate the smallest worthwhile effect of nonsteroidal anti-inflammatory drugs (NSAIDs) and physiotherapy for LBP. Patients seeking care for chronic LBP were interviewed by telephone before treatment commenced and 4 weeks later. RESULTS: Patients need to see a median of 30% (interquartile range [IQR]: 10-40) more improvement in pain and 20% (IQR: 10-40) more improvement in disability than would occur without intervention to perceive the effect of NSAIDs are worthwhile. They would need to see 20% (IQR: 0-30) more improvement on pain and disability over natural recovery to perceive that the effect of physiotherapy was worthwhile. There was no difference in estimates of the smallest worthwhile effect elicited at baseline and 4 weeks later. CONCLUSIONS: People with chronic back pain need to see larger effects on pain of NSAIDS than physiotherapy to consider the effects of these interventions worthwhile. These estimates of the smallest worthwhile effect can be used to interpret the findings of clinical trials and to design adequately powered clinical trials.
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