02235nas a2200205   4500000000100000008004100001100001400042700001300056700001900069700001200088700001300100700001400113700001600127245011400143250001500257300000900272490000700281520169000288020005101978       2015                            d1 aHeeley E.1 aArima H.1 aAnderson Craig1 aYang J.1 aZheng D.1 aKarpin A.1 aChalmers J.00aAmbient temperature and volume of perihematomal edema in acute intracerebral haemorrhage: the INTERACT1 study  a2014/10/28  a25-70 v103 a<p>
BACKGROUND: As no human data exist, we aimed to determine the relation between ambient temperature and volume of perihematomal 'cerebral' edema in acute spontaneous intracerebral haemorrhage (ICH) among Chinese participants of the pilot phase, Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT1). METHODS: INTERACT1 was a multicenter, open, blind outcome assessed, randomized controlled trial of intensive (systolic target &lt;140 mmHg) vs. guideline-recommended (systolic target &lt;180 mmHg) blood pressure (BP) lowering in 404 patients with acute ICH. Data on ambient temperature (mean, minimum, maximum, and range) on the day of each participant's ICH obtained from China Meteorological Data Sharing Service System were linked to other data including edema volumes. Multivariable regression analyses were performed to evaluate association between ambient temperature and edema volumes. A generalized linear regression model with a generalized estimating equations approach (GEE) was used to assess any association of ambient temperature and change in edema volume over 72 h. RESULTS: A total of 250 of all 384 Chinese participants had complete data that showed positive associations between ambient temperature (mean and minimum temperatures) and edema volumes at each time point over 72 h after hospital admission (all P &lt; 0.05). All temperature parameters except diurnal temperature range were positively associated with edema volume after adjustment for confounding variables (all P &lt; 0.02). CONCLUSION: An apparent positive association exists between ambient temperature and perihematomal edema volume in acute spontaneous ICH.
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