02624nas a2200397   4500000000100000008004100001653001000042653001100052653001100063653000900074653001600083653001100099653001700110653001400127653001600141653001900157653002600176653003300202653005900235653003700294653001800331100001400349700001400363700001300377700001400390700001500404700001400419700001500433700001900448245007700467250001500544300001100559490000700570520160300577020004602180       2015                            d10aAdult10aFemale10aHumans10aMale10aMiddle Aged10aApache10aTime Factors10aAustralia10aYoung Adult10aIntensive Care10aRetrospective Studies10aBody Temperature/ physiology10aBrain Injuries/complications/ physiopathology/ therapy10aFever/diagnosis/etiology/therapy10aMedical Audit1 aTaylor C.1 aSaxena M.1 aYoung P.1 aMyburgh J1 aHammond N.1 aMysore J.1 aMyburgh A.1 aBillot Laurent00aA multicentre audit of temperature patterns after traumatic brain injury  a2015/05/29  a129-340 v173 a<p>
BACKGROUND: Elevation of body temperature is common after traumatic brain injury (TBI). Suppressing fever may be beneficial. HYPOTHESIS: In clinical practice, temperature is maintained _37 degrees C. PARTICIPANTS, SETTING AND METHODS: A retrospective, multicentre, cohort study of patients with an intensive care unit admission diagnosis of TBI over a 6-month period. MAIN OUTCOME MEASURES: The mean proportion of time per day that temperature _37 degrees C or _38 degrees C (to correct for unequal measurements between patients, imputation was used between consecutive temperature measurements and a linear relationship was assumed); and the proportion of patients on each day with a peak temperature _37 degrees C. RESULTS: 217 patients with TBI were admitted to eight ICUs. The mean Acute Physiology and Chronic Health Evaluation II score of the cohort was 15.7 (SD, 7.7) and intracranial pressure monitoring was done in 29% of patients. The mean proportion of time on each day that temperature was _37 degrees C varied between 56% (SE, 2.6%) on Day 1 and 89% (SE, 3.7%) on Day 14. The mean proportion of time per day that temperature was &gt; 38 degrees C was between a minimum of 11% (SE, 1.5%) on Day 1 and a maximum of 25% (SE, 4.4%) Day 11. The proportion of patients for whom daily peak temperature was &gt; 37 degrees C ranged between a minimum of 73.2% (153/209) on Day 1 and a maximum of 97.4% (26/33) on Day 13. CONCLUSION: In patients with TBI, a substantial proportion of time is spent with a temperature _37 degrees C. Prospective validation of these data are required.
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