01812nas a2200205   4500000000100000008004100001100001300042700001200055700001900067700001300086700001400099700001600113700001100129245010700140250001500247300000800262050001600270520126900286020005101555       2016                            d1 aArima H.1 aSato S.1 aAnderson Craig1 aZheng D.1 aCarcel C.1 aChalmers J.1 aCao Y.00aCircadian variation in clinical features and outcome of intracerebral hemorrhage: The INTERACT studies  a2016/08/04  a1-6  a[IF]: 3.5403 a<p>
Previous studies consistently reported a diurnal variation in the occurrence of intracerebral hemorrhage (ICH), with a morning peak. However, limited knowledge exists on the circadian pattern of ICH severity and outcome. This study aimed to determine possible associations between ICH onset time and admission severity and 90-day outcomes using the combined data set of the pilot and main-phase Intensive blood pressure (BP) reduction in an acute cerebral hemorrhage trial (INTERACT). The ICH onset time was categorized into three groups (1: 00:00-07:59; 2: 08:00-15:59; and 3: 16:00-23:59). We found an association between onset time and low Glasgow Coma Scale score: aOR (time 1: 1.72, 95% CI 1.12-2.66; time 3: 1.95, 95% CI 1.31-2.89, p = 0.003; in comparison to time 2). There was no association between onset time and volume of ICH (adjusted p = 0.354) or 90-day outcomes of death or major disability, and death and major disability separately (all adjusted p &gt; 0.4). The results showed that more severe cases of ICH patients, defined by a reduced level of consciousness, had late afternoon to early morning stroke onset, but this was unrelated to baseline hematoma volume or location. There was no circadian influence on ICH clinical outcome.
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