02041nas a2200277   4500000000100000008004100001100001200042700001100054700001200065700001100077700001900088700001300107700001000120700001100130700001100141700001200152700001100164700001000175245010700185250001500292300001200307490000800319050001600327520136900343020005101712       2016                            d1 aWang J.1 aLiu M.1 aWong L.1 aWei J.1 aAnderson Craig1 aHuang Y.1 aWu Y.1 aSun W.1 aSun W.1 aXian Y.1 aLiu R.1 aLi F.00aObesity is associated with better survival and functional outcome after acute intracerebral hemorrhage  a2016/10/25  a140-1440 v370  a[IF]: 2.4743 a<p>
OBJECTIVE: To evaluate the association of obesity measured by body mass index (BMI) with mortality and functional outcome in patients with acute intracerebral hemorrhage (ICH). METHODS: Data were from 1571 patients with ICH enrolled in a national, multi-centre, prospective, hospital-based register: the ChinaQUEST (Quality Evaluation of Stroke Care and Treatment) study. The outcomes included all-cause mortality at 12months, and death or high dependency at 3 and 12months. High dependency was defined as a modified Rankin Scale score of 3-5. RESULTS: Of 1571 patients with ICH, 109 were underweight (BMI&lt;18.5kg/m2), 657 were normal-weight (BMI 18.5-23kg/m2), 341 were overweight (BMI 23-25kg/m2) and 464 were obese (BMI&gt;/=25kg/m2). Compared with normal-weight patients, obese patients had significantly decreased risks of death at 12months (HR: 0.71, 95% CI: 0.56-0.91) and death or high dependency at 3 and 12months (OR: 0.71, 95% CI: 0.53-0.95; OR: 0.69, 95% CI: 0.51-0.94) after adjusting for baseline characteristics. Neither underweight nor overweight was associated with these three outcomes significantly. CONCLUSIONS: In patients with acute ICH, being obese is associated with a decreased mortality and better functional recovery. Further interventional studies are needed to guide the weight management strategy for patients with ICH.
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