02589nas a2200337 4500000000100000008004100001653001100042653001100053653000900064653001700073653001500090653002800105653002600133653001900159653003200178653002500210653001800235100001400253700001800267700001500285700002600300700001600326700001500342700002000357700001600377245010600393300001200499490000800511520171800519022001402237 2017 d10aFemale10aHumans10aMale10aRisk Factors10aRecurrence10aCardiovascular Diseases10aCost-Benefit Analysis10aText Messaging10aQuality-Adjusted Life Years10aSecondary Prevention10aMarkov Chains1 aRodgers A1 aRedfern Julie1 aChow Clara1 aThiagalingam Aravinda1 aBurn Edward1 aNghiem Son1 aGraves Nicholas1 aJan Stephen00aCost-effectiveness of a text message programme for the prevention of recurrent cardiovascular events. a893-8940 v1033 a

OBJECTIVE: To estimate the cost-effectiveness of Tobacco, Exercise and Diet Messages (TEXT ME), a text message-based intervention that provides advice, motivation, information and support to improve health-related behaviours.

METHODS: A lifetime Markov model was used to estimate major vascular events (myocardial infarctions and strokes) avoided, quality-adjusted life years (QALYs) gained, costs to the health system and the incremental cost per QALY gained. The model was informed by data from a randomised controlled trial of TEXT ME, with evidence from systematic reviews and meta-analyses used to estimate the effects of changes in risk factors on the risk of major vascular events. Expected costs and health outcomes were estimated with uncertainty surrounding these characterised using probabilistic sensitivity analysis and a number of scenario analyses.

RESULTS: For a target population of 50 000 patients with documented coronary heart disease, the intervention is expected to lead to 563 fewer myocardial infarctions, 361 fewer strokes and 1143 additional QALYs. TEXT ME is expected to lead to an overall saving of $10.56 million for the health system over the patients' lifetimes. The intervention can therefore be considered cost-saving and health-improving. Neither parameter nor structural uncertainty had a significant impact on the conclusion that TEXT ME is cost-effective.

CONCLUSIONS: The provision of TEXT ME is predicted to lead to better health outcomes and an overall saving in costs for the health system.

TRIAL REGISTRATION NUMBER: anzctr.org.au identifier: ACTRN12611000161921.

 a1468-201X