02445nas a2200253   4500000000100000008004100001100001600042700001800058700001600076700001500092700001800107700001500125700001300140700001600153700001700169700001800186700001700204700001400221700001600235700001800251245008500269520182300354022001402177       2017                            d1 aZheng Danni1 aYou Shoujiang1 aYin Xiaowei1 aLiu Huihui1 aZhong Chongke1 aDu Huaping1 aZhang Yu1 aZhao Hongru1 aQiu Chenhong1 aFan Liangfeng1 aPei Shaofang1 aMa Zhaoxi1 aCao Yongjun1 aLiu Chun-Feng00aHyperfibrinogenemia and in-hospital mortality in acute ischemic stroke patients.3 a<p>
<b>BACKGROUND: </b>The impact of hyperfibrinogenemia on short-term outcomes after acute ischemic stroke (AIS) is still not understood.
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<b>OBJECTIVE: </b>We investigated the association between hyperfibrinogenemia upon hospital admission and the short-term prognosis of acute ischemic stroke (AIS) patients.
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<b>METHODS: </b>A total of 3,212 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. Hyperfibrinogenemia was defined as having a serum fibrinogen＞4.0g/L. Cox proportional hazard and logistic regression models were used to estimate the effect of hyperfibrinogenemia on all cause in-hospital mortality and discharge poor outcome (modified Rankin Scale score≥3) in AIS patients.
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<b>RESULTS: </b>During hospitalization, 106 patients (3.3%) died from all causes and 1226 (38.2%) patients experienced poor functional outcome at discharge. Multivariable model adjusted for age, sex, baseline National Institutes of Health Stroke Scale score, white blood cell count and other potential covariates, showed that hyperfibrinogenemia was associated with a 1.76-fold increase in the risk of in-hospital mortality (hazard ratio [HR] 1.76; 95% confidence interval [CI], 1.10-2.81; P-value=0.019). However, no significant association between hyperfibrinogenemia (odds ratios[OR]1.15; 95% CI 0.86-1.53; P-value=0.338) and poor outcome at discharge was observed after adjusting for potential confounders. Sensitivity and subgroup analyses further confirmed a significant association between hyperfibrinogenemia and a high risk of in-hospital mortality.
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<b>CONCLUSIONS: </b>In patients with AIS, hyperfibrinogenemia at admission was independently associated with in-hospital mortality.
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