02461nas a2200565 4500000000100000008004100001653001000042653001100052653001100063653000900074653000900083653001600092653001700108653001400125653001500139653003000154653002000184653002400204653001700228653002800245653001600273653001000289653002800299653003000327653001500357653002400372653003100396653003800427653003000465653001100495653003300506100001100539700001200550700001600562700001600578700001600594700001600610700001300626700002000639700002600659700001900685700001800704700002200722700002300744245006100767300001200828490000700840520103400847022001401881 2017 d 10 aAdult 10 aFemale 10 aHumans 10 aAged 10 aMale 10 aMiddle Aged 10 aRisk Factors 10 aPrognosis 10 aAdolescent 10 aSeverity of Illness Index 10 aResearch Design 10 aProspective Studies 10 aTime Factors 10 aCardiovascular Diseases 10 aYoung Adult 10 aIndia 10 aKidney Failure, Chronic 10 aRenal Replacement Therapy 10 abiomarkers 10 aDisease Progression 10 aGlomerular Filtration Rate 10 aGenetic Predisposition to Disease 10 aBiological Specimen Banks 10 aKidney 10 aRenal Insufficiency, Chronic 1 aJha V. 1 aJohn O. 1 aKumar Vivek 1 aYadav Ashok 1 aGang Sishir 1 aModi Gopesh 1 aOjha Jai 1 aPandey Rajendra 1 aParameswaran Sreejith 1 aPrasad Narayan 1 aSahay Manisha 1 aVarughese Santosh 1 aBaid-Agarwal Seema 00 aIndian chronic kidney disease study: Design and methods. a273-278 0 v22 3 a
AIM: The rate and factors that influence progression of chronic kidney disease (CKD) in developing countries like India are unknown. A pan-country prospective, observational cohort study is needed to address these knowledge gaps.
METHODS: The Indian Chronic Kidney Disease (ICKD) study will be a cohort study of approximately 5000 patients with mild to moderate CKD presenting to centres that represent different geographical regions in India. Time to 50% decline in baseline estimated glomerular filtration rate, need of renal replacement therapy or any new cardiovascular disease (CVD) event or death from CVD are the primary end points.
VALUE OF STUDY: This study will provide the opportunity to determine risk factors for CKD progression and development of CVD in Indian subjects and perform international comparisons to determine ethnic and geographical differences. A bio-repository will provide a chance to discover biomarkers and explore genetic risk factors.
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