02029nas a2200241   4500000000100000008004100001100001900042700001900061700001500080700001800095700002000113700002100133700001700154700001700171700002400188700002000212700002800232700002000260245012500280300002100405520134700426022001401773       2018                            d1 aAnderson Craig1 aArima Hisatomi1 aBrown Alex1 aThrift Amanda1 aBalabanski Anna1 aNewbury Jonathan1 aLeyden James1 aCastle Sally1 aCranefield Jennifer1 aPaterson Tracey1 aKatzenellenbogen Judith1 aKleinig Timothy00aExcess stroke incidence in young Aboriginal people in South Australia: Pooled results from two population-based studies.  a17474930187781133 a<p>Background Retrospective data indicate increased stroke incidence in Aboriginal/Torres Strait Islander (Indigenous) Australians, possibly with poorer outcomes. We present the first prospective population-based stroke incidence study in Indigenous Australians. Methods We pooled data from ASCEND and SEARCH, two prospective "ideal" South Australian stroke incidence studies, ASCEND conducted in urban Northwestern Adelaide (2009-2010) and SEARCH in five South Australian rural centers (2009-2011). We calculated age-standardized incidence for Aboriginal and non-Aboriginal people. Results The study population comprised 261,403 inhabitants. Among 432 first-ever strokes, 13 were in Aboriginal people (median age 51 vs. 78 years for non-Aboriginal people, p < 0.001). Age-standardized stroke incidence per 100,000 in Aboriginal patients (116, 95% CI: 95-137) was nearly two-fold that of non-Aboriginal patients (67, 95% CI: 51-84). Age-stratified excess incidence in Aboriginal people was restricted to those aged < 55 years (incidence rate ratio (IRR) 3.5, 95% CI: 2-7), particularly for intracerebral hemorrhage (IRR: 16, 95% CI: 4-61). Conclusion The excess stroke incidence in Aboriginal South Australians appears substantial, especially in those aged <55 years. Further work is required to delineate and address disparities.</p>  a1747-4949