J Clin Hypertens (Greenwich). 2011;13;693-702. (c)2011 Wiley Periodicals, Inc. The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized placebo-controlled trial which clearly demonstrated that perindopril-based blood pressure (BP)-lowering treatment is one of the most effective and generalizable strategies for secondary prevention of stroke. Beneficial effects of BP lowering were observed on recurrent stroke, other cardiovascular events, disability, dependency, and cognitive function across a variety of subgroups defined by age, sex, geographical region, body mass index, diabetes, atrial fibrillation, chronic kidney disease, and baseline BP levels. Once patients with stroke have stabilized, all patients should receive BP-lowering therapy irrespective of their BP levels. On the basis of recommendations from current international guidelines, BP should be lowered to <140/90 mm Hg in all patients with cerebrovascular disease and to <130/80 mm Hg if therapy is well tolerated.
AD - From The George Institute for Global Health, University of Sydney and the Royal Prince Alfred Hospital, Sydney, Australia. AN - 21896153 BT - Journal of Clinical Hypertension (Greenwich) ET - 2011/09/08 LA - eng M1 - 9 N1 - Arima, HisatomiChalmers, JohnUnited StatesJournal of clinical hypertension (Greenwich, Conn.)J Clin Hypertens (Greenwich). 2011 Sep;13(9):693-702. doi: 10.1111/j.1751-7176.2011.00530.x. Epub 2011 Sep 2. N2 -J Clin Hypertens (Greenwich). 2011;13;693-702. (c)2011 Wiley Periodicals, Inc. The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a randomized placebo-controlled trial which clearly demonstrated that perindopril-based blood pressure (BP)-lowering treatment is one of the most effective and generalizable strategies for secondary prevention of stroke. Beneficial effects of BP lowering were observed on recurrent stroke, other cardiovascular events, disability, dependency, and cognitive function across a variety of subgroups defined by age, sex, geographical region, body mass index, diabetes, atrial fibrillation, chronic kidney disease, and baseline BP levels. Once patients with stroke have stabilized, all patients should receive BP-lowering therapy irrespective of their BP levels. On the basis of recommendations from current international guidelines, BP should be lowered to <140/90 mm Hg in all patients with cerebrovascular disease and to <130/80 mm Hg if therapy is well tolerated.
PY - 2011 SN - 1751-7176 (Electronic)1524-6175 (Linking) SP - 693 EP - 702 T2 - Journal of Clinical Hypertension (Greenwich) TI - PROGRESS: Prevention of Recurrent Stroke VL - 13 ER -