BACKGROUND AND PURPOSE: Because little evidence exists and the topic often raises concerns, we aimed to determine the relationship between life events and subarachnoid hemorrhage (SAH) in a population-based case-control setting. METHODS: In 388 SAH incident cases and 473 frequency-matched community SAH-free control subjects, information on the occurrence of 12 types of adverse life events in the preceding 1 and 2 to 12 months was obtained by interview using a questionnaire based on the Social Behavior Assessment Schedule. Analyses involved logistic regression models with adjustment for confounding variables. RESULTS: Among 12 life events, only 2 ("financial/legal problems" and "other") in the past month were marginally associated with SAH (P=0.04 and 0.03, respectively), whereas "physical attack/assault" and "injury/disease of a relative/friend/pet" during the past 2 to 12 months also showed similarly marginally significant and imprecise associations (inversely) with SAH. There were no clear associations between multiple life events and SAH for both the prior month and 2 to 12 months (both P>0.4). CONCLUSIONS: Life events are unlikely to have appreciable effects on the risk of SAH.
AD - The George Institute for International Health, Royal Prince Alfred Hospital and the University of Sydney, PO Box M201, Missenden Road, NSW 2050, Australia. AN - 20395616 BT - Stroke ET - 2010/04/17 LA - eng M1 - 6 N1 - Shiue, IvyArima, HisatomiAnderson, Craig SACROSS GroupMulticenter StudyResearch Support, Non-U.S. Gov'tUnited StatesStroke; a journal of cerebral circulationStroke. 2010 Jun;41(6):1304-6. Epub 2010 Apr 15. N2 -BACKGROUND AND PURPOSE: Because little evidence exists and the topic often raises concerns, we aimed to determine the relationship between life events and subarachnoid hemorrhage (SAH) in a population-based case-control setting. METHODS: In 388 SAH incident cases and 473 frequency-matched community SAH-free control subjects, information on the occurrence of 12 types of adverse life events in the preceding 1 and 2 to 12 months was obtained by interview using a questionnaire based on the Social Behavior Assessment Schedule. Analyses involved logistic regression models with adjustment for confounding variables. RESULTS: Among 12 life events, only 2 ("financial/legal problems" and "other") in the past month were marginally associated with SAH (P=0.04 and 0.03, respectively), whereas "physical attack/assault" and "injury/disease of a relative/friend/pet" during the past 2 to 12 months also showed similarly marginally significant and imprecise associations (inversely) with SAH. There were no clear associations between multiple life events and SAH for both the prior month and 2 to 12 months (both P>0.4). CONCLUSIONS: Life events are unlikely to have appreciable effects on the risk of SAH.
PY - 2010 SN - 1524-4628 (Electronic)0039-2499 (Linking) SP - 1304 EP - 6 T2 - Stroke TI - Life events and risk of subarachnoid hemorrhage: the australasian cooperative research on subarachnoid hemorrhage study (ACROSS) VL - 41 ER -