BACKGROUND: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations. METHODS: Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates. RESULTS: A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed. CONCLUSIONS: In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations.
AD - Medical Research Council Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK. david-b@sphsu.mrc.ac.uk AN - 19889610 BT - Annals of Oncology ET - 2009/11/06 LA - eng M1 - 3 N1 - Batty, G DBarzi, FWoodward, MJamrozik, KWoo, JKim, H CUeshima, HHuxley, R RAsia Pacific Cohort Studies CollaborationMedical Research Council/United KingdomComparative StudyResearch Support, Non-U.S. Gov'tEnglandAnnals of oncology : official journal of the European Society for Medical Oncology / ESMOAnn Oncol. 2010 Mar;21(3):646-54. Epub 2009 Nov 4. N2 -BACKGROUND: The observation that taller people experience an increased risk of selected cancers is largely restricted to Caucasian cohorts. These associations may plausibly differ in Asian populations. For the first time, we make direct comparison in the same analyses of the associations between height and a series of malignancies in Australasian (Caucasian) and Asian populations. METHODS: Analyses were based on the Asia Pacific Cohort Studies Collaboration of 506 648 study participants (408 381 Asia, 98 267 Australasia) drawn from 38 population-based cohort studies. Cox proportional hazards regression was used to estimate the relationship between height and cancer rates. RESULTS: A total of 3 272 600 person-years of follow-up gave rise to 7497 cancer deaths (4415 in Asia; 3082 in Australasia). After multiple adjustments and left censoring, taller individuals experienced increased rates of carcinoma of the intestine (men and women); all cancers, liver, lung, breast, 'other' malignancies (all women); and cancers of the prostate and bladder (men). No consistent regional (Asia versus Australasia) or sex differences were observed. CONCLUSIONS: In the present study, taller men and women had an elevated risk of selected malignancies. These associations did not differ appreciably between Asian and Caucasian populations.
PY - 2010 SN - 1569-8041 (Electronic)0923-7534 (Linking) SP - 646 EP - 54 T2 - Annals of Oncology TI - Adult height and cancer mortality in Asia: the Asia Pacific Cohort Studies Collaboration VL - 21 ER -