TY - JOUR
AU - Kohli H.
AU - Ramachandran R.
AU - Gupta K.
AU - Jha V.
AU - Nada R.
AU - Kumar V
AU - Kumar A.
AU - Suri D.
AU - Gupta A.
AB - <p>
Idiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m-type phospholipase A2 receptor (PLA2R) are seen in two-thirds of adult IMN cases. PLA2R staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN cases, respectively. However, there are no reports of anti-PLA2R in paediatric IMN. We evaluated anti-PLA2R levels and PLA2R in gloemrular deposits in paediatric IMN seen at our center. Five cases were enrolled, all the cases stained for PLA2R in glomeruli and three (60%) had antibodies to PLA2R antigen. There was a parellel reduction in proteinuria and anti-PLA2R titer. The present report suggests that PLA2R has a contributory role in the pathogenesis of paediatric IMN.
</p>

AD - Department of Nephrology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.<br/>Department of Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.<br/>Department of Paediatric Allergy and Immunology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.<br/>George Institute for Global Health, New Delhi, India.
AN - 26194981
BT - Nephrology (Carlton)
DP - NLM
ET - 2015/07/22
LA - eng
LB - INDIA
M1 - 8
N1 - Kumar, Vinod<br/>Ramachandran, Raja<br/>Kumar, Ashwani<br/>Nada, Ritambhra<br/>Suri, Deepti<br/>Gupta, Anju<br/>Kohli, Harbir Singh<br/>Gupta, Krishan Lal<br/>Jha, Vivekanand<br/>Australia<br/>Nephrology (Carlton). 2015 Aug;20(8):572-5. doi: 10.1111/nep.12478.
N2 - <p>
Idiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m-type phospholipase A2 receptor (PLA2R) are seen in two-thirds of adult IMN cases. PLA2R staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN cases, respectively. However, there are no reports of anti-PLA2R in paediatric IMN. We evaluated anti-PLA2R levels and PLA2R in gloemrular deposits in paediatric IMN seen at our center. Five cases were enrolled, all the cases stained for PLA2R in glomeruli and three (60%) had antibodies to PLA2R antigen. There was a parellel reduction in proteinuria and anti-PLA2R titer. The present report suggests that PLA2R has a contributory role in the pathogenesis of paediatric IMN.
</p>

PY - 2015
SN - 1440-1797 (Electronic)<br/>1320-5358 (Linking)
SP - 572
EP - 5
T2 - Nephrology (Carlton)
TI - Antibodies to m-type phospholipase A2 receptor in children with idiopathic membranous nephropathy
VL - 20
Y2 - FY16
ER -