TY - JOUR AU - Remuzzi G. AU - Garcia-Garcia G. AU - Zhang J. AU - Tonelli M. AU - Lewington A. AU - Rocco M. AU - Jha V. AU - Mehta R. AU - Cerda J. AU - Burdmann E. AU - Lameire N. AU - Lombardi R. AU - Feehally J. AU - Finkelstein F. AU - Aronoff-Spencer E. AU - Godin M. AU - Levin N. AU - Macedo E. AB -

BACKGROUND: Epidemiological data for acute kidney injury are scarce, especially in low-income countries (LICs) and lower-middle-income countries (LMICs). We aimed to assess regional differences in acute kidney injury recognition, management, and outcomes. METHODS: In this multinational cross-sectional study, 322 physicians from 289 centres in 72 countries collected prospective data for paediatric and adult patients with confirmed acute kidney injury in hospital and non-hospital settings who met criteria for acute kidney injury. Signs and symptoms at presentation, comorbidities, risk factors for acute kidney injury, and process-of-care data were obtained at the start of acute kidney injury, and need for dialysis, renal recovery, and mortality recorded at 7 days, and at hospital discharge or death, whichever came earlier. We classified countries into high-income countries (HICs), upper-middle-income countries (UMICs), and combined LICs and LMICs (LLMICs) according to their 2014 gross national income per person. FINDINGS: Between Sept 29 and Dec 7, 2014, data were collected from 4018 patients. 2337 (58%) patients developed community-acquired acute kidney injury, with 889 (80%) of 1118 patients in LLMICs, 815 (51%) of 1594 in UMICs, and 663 (51%) of 1241 in HICs (for HICs vs UMICs p=0.33; p<0.0001 for all other comparisons). Hypotension (1615 [40%] patients) and dehydration (1536 [38%] patients) were the most common causes of acute kidney injury. Dehydration was the most frequent cause of acute kidney injury in LLMICs (526 [46%] of 1153 vs 518 [32%] of 1605 in UMICs vs 492 [39%] of 1260 in HICs) and hypotension in HICs (564 [45%] of 1260 vs 611 [38%%] of 1605 in UMICs vs 440 [38%] of 1153 LLMICs). Mortality at 7 days was 423 (11%) of 3855, and was higher in LLMICs (129 [12%] of 1076) than in HICs (125 [10%] of 1230) and UMICs (169 [11%] of 1549). INTERPRETATION: We identified common aetiological factors across all countries, which might be amenable to a standardised approach for early recognition and treatment of acute kidney injury. Study limitations include a small number of patients from outpatient settings and LICs, potentially under-representing the true burden of acute kidney injury in these areas. Additional strategies are needed to raise awareness of acute kidney injury in community health-care settings, especially in LICs. FUNDING: International Society of Nephrology.

AD - Department of Medicine, University of California San Diego, San Diego, CA, USA. Electronic address: rmehta@ucsd.edu.
LIM 12, Division of Nephrology, University of Sao Paulo Medical School, Sao Paulo, Brazil.
Division of Nephrology, Department of Medicine, Albany Medical College, Albany, NY, USA.
Renal Medicine, University of Leicester, Leicester, UK.
Yale University, New Haven, CT, USA.
Hospital Civil de Guadalajara, University of Guadalajara Health Sciences Center, Guadalajara, Jalisco, Mexico.
Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
The George Institute for Global Health India, University of Oxford, Oxford, UK.
Nephrology Section, Department of Internal Medicine, University Hospital, Ghent, Belgium.
Mount Sinai School of Medicine, Renal Research Institute, New York, NY, USA.
Department of Nephrology, Leeds Teaching Hospitals, Leeds, UK.
Department of Critical Care Medicine, Servicio Medico Integral, Montevideo, Uruguay.
Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Medicine, University of California San Diego, San Diego, CA, USA.
University of Calgary, Calgary, AB, Canada.
IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy; Department of Medicine, Unit of Nephrology, Dialysis and Transplantation, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AN - 27086173 BT - Lancet DA - 169488475183 DP - NLM ET - 2016/04/18 LA - Eng LB - UK
INDIA
FY16 M1 - 10032 N1 - Mehta, Ravindra L
Burdmann, Emmanuel A
Cerda, Jorge
Feehally, John
Finkelstein, Fredric
Garcia-Garcia, Guillermo
Godin, Melanie
Jha, Vivekanand
Lameire, Norbert H
Levin, Nathan W
Lewington, Andrew
Lombardi, Raul
Macedo, Etienne
Rocco, Michael
Aronoff-Spencer, Eliah
Tonelli, Marcello
Zhang, Jing
Remuzzi, Giuseppe
Lancet. 2016 Apr 13. pii: S0140-6736(16)30240-9. doi: 10.1016/S0140-6736(16)30240-9. N2 -

BACKGROUND: Epidemiological data for acute kidney injury are scarce, especially in low-income countries (LICs) and lower-middle-income countries (LMICs). We aimed to assess regional differences in acute kidney injury recognition, management, and outcomes. METHODS: In this multinational cross-sectional study, 322 physicians from 289 centres in 72 countries collected prospective data for paediatric and adult patients with confirmed acute kidney injury in hospital and non-hospital settings who met criteria for acute kidney injury. Signs and symptoms at presentation, comorbidities, risk factors for acute kidney injury, and process-of-care data were obtained at the start of acute kidney injury, and need for dialysis, renal recovery, and mortality recorded at 7 days, and at hospital discharge or death, whichever came earlier. We classified countries into high-income countries (HICs), upper-middle-income countries (UMICs), and combined LICs and LMICs (LLMICs) according to their 2014 gross national income per person. FINDINGS: Between Sept 29 and Dec 7, 2014, data were collected from 4018 patients. 2337 (58%) patients developed community-acquired acute kidney injury, with 889 (80%) of 1118 patients in LLMICs, 815 (51%) of 1594 in UMICs, and 663 (51%) of 1241 in HICs (for HICs vs UMICs p=0.33; p<0.0001 for all other comparisons). Hypotension (1615 [40%] patients) and dehydration (1536 [38%] patients) were the most common causes of acute kidney injury. Dehydration was the most frequent cause of acute kidney injury in LLMICs (526 [46%] of 1153 vs 518 [32%] of 1605 in UMICs vs 492 [39%] of 1260 in HICs) and hypotension in HICs (564 [45%] of 1260 vs 611 [38%%] of 1605 in UMICs vs 440 [38%] of 1153 LLMICs). Mortality at 7 days was 423 (11%) of 3855, and was higher in LLMICs (129 [12%] of 1076) than in HICs (125 [10%] of 1230) and UMICs (169 [11%] of 1549). INTERPRETATION: We identified common aetiological factors across all countries, which might be amenable to a standardised approach for early recognition and treatment of acute kidney injury. Study limitations include a small number of patients from outpatient settings and LICs, potentially under-representing the true burden of acute kidney injury in these areas. Additional strategies are needed to raise awareness of acute kidney injury in community health-care settings, especially in LICs. FUNDING: International Society of Nephrology.

PY - 2016 SN - 1474-547X (Electronic)
0140-6736 (Linking) SP - 2017 EP - 25 T2 - Lancet TI - Recognition and management of acute kidney injury in the International Society of Nephrology 0by25 Global Snapshot: a multinational cross-sectional study VL - 387 Y2 - FY16 ER -