BACKGROUND: The impact of hyperfibrinogenemia on short-term outcomes after acute ischemic stroke (AIS) is still not understood.
OBJECTIVE: We investigated the association between hyperfibrinogenemia upon hospital admission and the short-term prognosis of acute ischemic stroke (AIS) patients.
METHODS: A total of 3,212 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. Hyperfibrinogenemia was defined as having a serum fibrinogen＞4.0g/L. Cox proportional hazard and logistic regression models were used to estimate the effect of hyperfibrinogenemia on all cause in-hospital mortality and discharge poor outcome (modified Rankin Scale score≥3) in AIS patients.
RESULTS: During hospitalization, 106 patients (3.3%) died from all causes and 1226 (38.2%) patients experienced poor functional outcome at discharge. Multivariable model adjusted for age, sex, baseline National Institutes of Health Stroke Scale score, white blood cell count and other potential covariates, showed that hyperfibrinogenemia was associated with a 1.76-fold increase in the risk of in-hospital mortality (hazard ratio [HR] 1.76; 95% confidence interval [CI], 1.10-2.81; P-value=0.019). However, no significant association between hyperfibrinogenemia (odds ratios[OR]1.15; 95% CI 0.86-1.53; P-value=0.338) and poor outcome at discharge was observed after adjusting for potential confounders. Sensitivity and subgroup analyses further confirmed a significant association between hyperfibrinogenemia and a high risk of in-hospital mortality.
CONCLUSIONS: In patients with AIS, hyperfibrinogenemia at admission was independently associated with in-hospital mortality.
BT - Curr Neurovasc Res DO - 10.2174/1567202614666170621103604 J2 - Curr Neurovasc Res LA - eng N2 -BACKGROUND: The impact of hyperfibrinogenemia on short-term outcomes after acute ischemic stroke (AIS) is still not understood.
OBJECTIVE: We investigated the association between hyperfibrinogenemia upon hospital admission and the short-term prognosis of acute ischemic stroke (AIS) patients.
METHODS: A total of 3,212 AIS patients enrolled from December 2013 to May 2014 across 22 hospitals in Suzhou city were included in the present study. Hyperfibrinogenemia was defined as having a serum fibrinogen＞4.0g/L. Cox proportional hazard and logistic regression models were used to estimate the effect of hyperfibrinogenemia on all cause in-hospital mortality and discharge poor outcome (modified Rankin Scale score≥3) in AIS patients.
RESULTS: During hospitalization, 106 patients (3.3%) died from all causes and 1226 (38.2%) patients experienced poor functional outcome at discharge. Multivariable model adjusted for age, sex, baseline National Institutes of Health Stroke Scale score, white blood cell count and other potential covariates, showed that hyperfibrinogenemia was associated with a 1.76-fold increase in the risk of in-hospital mortality (hazard ratio [HR] 1.76; 95% confidence interval [CI], 1.10-2.81; P-value=0.019). However, no significant association between hyperfibrinogenemia (odds ratios[OR]1.15; 95% CI 0.86-1.53; P-value=0.338) and poor outcome at discharge was observed after adjusting for potential confounders. Sensitivity and subgroup analyses further confirmed a significant association between hyperfibrinogenemia and a high risk of in-hospital mortality.
CONCLUSIONS: In patients with AIS, hyperfibrinogenemia at admission was independently associated with in-hospital mortality.
PY - 2017 T2 - Curr Neurovasc Res TI - Hyperfibrinogenemia and in-hospital mortality in acute ischemic stroke patients. SN - 1875-5739 ER -