TY - JOUR
AU - Group GEM
AU - Dwyer T
AU - Venn Alison
AU - Thomas Nancy
AU - Kanetsky Peter
AU - Armstrong Bruce
AU - Cust Anne
AU - Anton-Culver Hoda
AU - Gruber Stephen
AU - Luo Li
AU - Orlow Irene
AU - Gallagher Richard
AU - Zanetti Roberto
AU - Rosso Stefano
AU - Sacchetto Lidia
AU - Begg Colin
AU - Berwick Marianne
AU - Shi Yang
AU - Corrales-Guerrero Sergio
AU - Marrett Loraine
AU - Busam Klaus
AB - <p>Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.</p>
BT - Pigment Cell Melanoma Res
C1 - https://www.ncbi.nlm.nih.gov/pubmed/28990310?dopt=Abstract
DO - 10.1111/pcmr.12653
IS - 2
J2 - Pigment Cell Melanoma Res
LA - eng
N2 - <p>Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.</p>
PY - 2018
SP - 287
EP - 296
T2 - Pigment Cell Melanoma Res
TI - The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.
VL - 31
SN - 1755-148X
ER -