Randomised controlled trials

New Course on Randomised Clinical Trials

The George Institute for Global Health is launching a new course, Introduction to Randomised Clinical Trials (RCTs), to build capacity and strengthen evidence-based approaches to global health challenges.

RCTs are considered to produce the highest quality of evidence on the effects of interventions because of their ability to minimise bias. Critical to successful generation of high-quality evidence through RCTs is the knowledge and skills to properly design, conduct, analyse and report them.

“RCTs are extremely important in medical research and we’re very proud to be offering this course to equip the next generation of researchers with the knowledge and tools they need to contribute to future advances in global health” - Helen Monaghan, Director, Global Project Operations, Centre for Operational and Research Excellence, The George Institute, Australia

The 12 to 13 week online course beginning on 07 June 2022 will be delivered by experienced researchers and trial managers at The George Institute. It will provide early career researchers (The George Institute staff, consultants, students, visiting fellows, collaborators, and partners) with a comprehensive introduction to the fundamentals of RCTs, including effective trial management.

This course will harness the knowledge gained and skills developed over more than 20 years of ground-breaking RCTs carried out at The George Institute. After completing this course, participants will have understanding of the strengths and limitations of RCTS and how they can be applied to have real world impact and improve people’s health.” - Niveditha Devasenapathy, Lead, Better Treatments, The George Institute, India

Contact

Abdul Salam
The George Institute for Global Health
researchtraining@georgeinstitute.org

Kate Ballard
The George Institute for Global Health
researchtraining@georgeinstitute.org

National Preventive Health Strategy 2021-2030

George Institute calls for commitment to prevention ahead of federal election

Open letter to Australia’s next government, 16 May 2022

Ahead of the 2022 Federal election, The George Institute for Global Health calls on all political parties to commit to developing a clear and explicit implementation plan for the National Preventive Health Strategy’s ‘Blueprint for Action’ in the first 100 days of government.

The National Preventive Health Strategy 2021-2030 (NPHS) is an important milestone and a credible and evidence-based strategy that will, if properly funded and implemented, deliver a healthier, more equitable Australia. Australian governments, the health sector and community members have worked together to develop the strategy. To date, no political party has committed to funding the implementation of this strategy during the 2022 election cycle.

Commitment to the goals of the NPHS, coupled with appropriate investment, is urgently needed to reverse the spiralling growth in disease burden and to help protect the health of all Australians.

Nearly half of all Australians have one or more chronic condition, such as cardiovascular disease, cancer or type 2 diabetes. Yet, Australia’s per capita expenditure on preventive health ranks in the bottom half of OECD countries.

As Australia heads to the ballot box, we call on all political parties to commit to a concrete plan for implementing the NPHS ‘Blueprint for Action’ in the first 100 days of government.

Key priorities for action in the NPHS include:

  • Invest in prevention by committing 5% of health expenditure to prevention.
  • Launch an independent, expert-led governance process to advise on prevention priorities and the use of the prevention fund.
  • Futureproof the public health workforce by developing and enhancing expertise and capacity, including digital training and improved health systems infrastructure.
  • Improve health literacy by creating a national health information platform to empower consumers.
  • Link prevention with primary care by aligning the Blueprint for Action with the Primary Health Care 10 Year Plan and the National Aboriginal and Torres Strait Islander Health Plan.
  • Develop evidence-based preventive health mechanisms by investing in a robust research sector.
  • Strengthen health equity by ensuring an equity lens underpins preventive health, prioritising Aboriginal and Torres Strait Islander people and other communities experiencing vulnerability.
  • Build innovative partnerships and develop consumer engagement between and within sectors, using the National Consumer Engagement Strategy 2021-2030.
  • Boost action in target focus areas such as anti-smoking, healthier diets and environments to deliver early wins in reducing the burden of disease at population level.

Australia’s healthcare system enables citizens to enjoy world-class treatments and programs, underpinned by a robust research sector. But effective governments don’t just invest in treating health problems – they invest in preventing them, especially for the most at-risk communities. Every dollar spent on prevention leads to better outcomes and significant health-system savings.

banner George Institute event

International #ClinicalTrials Day | Panel Discussion: Patient and Public Involvement in Clinical Trials in India

International Clinical Trials Day

Clinical trials are important tools to generate evidence about the safety and benefit of medical interventions- be it a drug, device, or vaccine. Although advancement in science is beginning to change the way we understand health care, it is still lagging in involving patients and the public in their own healthcare decisions including in the clinical trials.

Patients and the public continue to be regarded as a source of data and not as the true protagonists in the clinical trial process. Even though initiatives have been taken in recent years to change this situation, quite often the efforts have remained tokenistic- defeating the whole purpose of their meaningful involvement. The deep-seated power imbalance in society also impacts equitable patients and public involvement in clinical trials.

To mark the International Clinical Trials Day on 20th May 2022, The George Institute is organising a panel discussion to expand the awareness about the importance of patient and public involvement in clinical trials and include stakeholders’ perspectives in involving patients and the public throughout a clinical trial.

Objectives

  • To increase awareness about the patient and public involvement (PPI) in clinical trials in India
  • To provide a platform for all stakeholders involved in a clinical trial to share their roles and their perspectives on patient and public involvement throughout the clinical trial
  • To discuss challenges, barriers, and opportunities, and find innovative solutions for PPI in research processes

Save the Date

Mark your calendars for 20th May 2022 | 11:00 AM IST

Country Specific Timings

CountryLocal time
India11:00 IST
Australia15:30 AEST
United Kingdom06:30 BST
United States of America01:30 EST
China13:30 CST

Speakers

  • Dr Bharath Kumar - Intensivist Apollo Chennai & Honorary Fellow, The George Institute for Global Health, India

    Dr Bharath Kumar Tirupakuzhi Vijayaraghavan is a Clinician Researcher based at the Department of Critical Care Medicine at Apollo Hospitals in Chennai and an Honorary Senior Fellow at the George Institute for Global Health, India. He has formal training in clinical trial methodology and leads and collaborates on several COVID and non-COVID trials. Bharath is also the National Coordinator for the Indian Registry of Intensive care and is pursuing a PhD with the University of Amsterdam focused on how critical care registries can help overcome barriers to conducting research in resource-limited settings.

    Dr Bharath Kumar - Intensivist Apollo Chennai & Honorary fellow, The George Institute for Global Health, India
  • Dr Anant Bhan - Independent Researcher, Bioethics and Global Health

    Dr Anant Bhan is a trained medical doctor with a Master’s degree in bioethics from the University of Toronto. He is an Adjunct Visiting Professor, at Yenepoya (Deemed to be University), India. Anant is the Former President, of the International Association of Bioethics. His work is focused on ethics and equity in health, mental health, digital health, public health ethics, research ethics, community engagement, ethics of innovative technologies and ethics training for professionals. He also serves as the Bhopal hub lead for Sangath and is the site-PI for the various projects conducted at the hub.

    Dr Anant Bhan Researcher, Bioethics and Global Health
  • Dr Aparna Mukherjee - Scientist (Medical), Indian Council of Medical Research (ICMR)

    Dr Aparna Mukherjee is working with the Trials & Projection Unit at the Epidemiology & Communicable Diseases Division, Indian Council of Medical Research, New Delhi. She is leading the clinical trial network launched by ICMR – Indian Clinical Trial and Education Network (INTENT). She has been involved in multiple studies on COVID-19 including a randomized controlled trial on convalescent plasma (PLACID Trial) for COVID-19 and the ongoing National Clinical Registry of COVID-19. Aparna is a recipient of the prestigious Physician-Scientist Fellowship from Wellcome Trust/ India Alliance and has completed her MBBS and MD (Paediatrics) from Medical College, Kolkata and was awarded PhD (Paediatrics) by AIIMS, Delhi.

    Dr Aparna Mukherjee Scientist Indian Council of Medical Research
  • DVL Padma Priya - Editor-in-Chief, Suno India

    DVL Padma Priya is the Co-Founder and Editor-in-Chief of Suno India, an award winning podcast platform bringing quality audio journalism. She has hosted multiple podcasts on under-reported stories such as "Dear Pari" on adoption, "The Suno India Show" on current affairs and award winning show "Pinjra Tod Kar" on women empowerment to name a few. She is also the founder of India Covid Survivors Group, a peer support group dedicated for those who survived COVID as well as those facing long covid issues. As a long covid survivor herself, she has been a relentless patient advocate and continues to raise awareness about Long Covid.

    As an independent journalist she has written for many leading media houses in India and has. She has also worked as an advocacy and communication specialist for the Nobel Peace Prize-winning organisation Doctors Without Borders.

     Padma Priya, suno india
  • Moderator: Dr Niveditha Devasenapathy - Lead Better Treatments, The George Institute for Global health, India

    Dr Niveditha Devasenapathy is trained in clinical research and applied statistics with over 15 years of experience in clinical and public health research. She is a recipient of the prestigious DBT/Wellcome Trust–India Alliance Intermediate Clinical and Public Health fellowship (2020) for the design and evaluation of a technology-based post knee arthroplasty rehabilitation monitoring strategy. She has been involved in the design and analysis of several multicentre randomised controlled trials in maternal health and cardiovascular disease. She is a completed her Master's in clinical trials from the London School of Hygiene and Tropical Medicine and PhD from Deakin University, Australia. She currently leads the Better Treatment strategic priority area at The George Institute for Global Health.

    Dr Niveditha Devasenapathy, Better Treatments, The George Institute for Global health, India
Event

'Clinical Trials – Are Global trials truly Global? How can LMICs play a more central role?'

Tea-with-Africa-salt

The George Institute for Global Health invites you to the second session of the 'Tea with Africa' series on Tuesday 24 May at 6:30pm AEST, 2:00pm IST, 9:30am WAT, 9:00am BST, 10:30am CAT, 11:30am EAT: 'Clinical Trials – Are Global trials truly Global? How can LMICs play a more central role?’

The 'Tea with Africa' series is part of our Africa Partnership Initiative, and aims to facilitate collaboration and learning. Each event provides an opportunity for outreach and connection with the global health community.

In an informal setting, panellists from across Africa and The George Institute in different regions will share perspectives on a global health topic. Following this, discussion and interaction with the audience is encouraged, to exchange unique challenges and solutions and discuss implications for different regions. Audience participants who would like to contribute further or build connections are invited to share contact details and/or send reflections from the event for potential inclusion in the post event wrap-up blog.

The second of the series will focus on 'Clinical Trials – Are Global trials truly Global? How can LMICs play a more central role?'. Each speaker will talk for around 4 minutes, with the majority of time dedicated to discussion and Q&A with the audience. 

•  Dr Emmy Okello
•  Prof Rati Ndhlovu
•  Dr. Niveditha Devasenapathy

Host Olive Kobusingye will facilitate the discussion among speakers and with the audience.

Speakers

  • Dr. Emmy Okello

    Dr. Emmy Okello is chief of cardiology at the Uganda Heart Institute and honorary associate professor at Makerere University. Okello graduated from Mbarara University School of Medicine and earned his Ph.D. from Makerere University. He received advanced training at Case Western Reserve University through a fellowship of the Medical Education Partnership Initiative (MEPI) - managed by Fogarty and funded by PEPFAR, the NIH Common Fund and the National Heart, Lung and Blood Institute. Dr. Okello has recenty led two large clinical trials in Uganda.

    Emmy Okello
  • Professor Chriatidzo Ndhlovu

    Professor Chriatidzo Ndhlovu is an Associate Professor in the Internal Medicine Unit in the Faculty of Medicine and Health Sciences at the University of Zimbabwe. As a medical educator and clinician involved in nephrology and HIV medicine, she has vast experience in internal medicine, renal care and care of HIV patients in a resource-limited settings. Her current research is mainly in cryptococcal meningitis and COVID-19 vaccine hesitancy.

    Chriatidzo Ndhlovu
  • Dr. Niveditha Devasenapathy

    Dr. Niveditha Devasenapathy is a medical doctor, trained in clinical research and applied statistics with over 15 years of experience in clinical and public health research. She currently leads The Better Treatments program at The George Institute, India office. She is a recipient of the prestigious DBT/Wellcome Trust–India alliance Intermediate Clinical and Public Health fellowship (2020) for the design and evaluation of a technology-based post knee arthroplasty rehabilitation monitoring strategy. She has been involved in the design and analysis of several multicentre randomised controlled trials in maternal health and cardiovascular disease.

    Niveditha Devasenapathy
  • Host: Dr Olive Kobusingye

    Olive Kobusingye is an accident & emergency surgeon, injury epidemiologist, and published author. She is Director of the Trauma, Injuries and Disability programme at the Makerere University School of Public Health in Kampala, Board Chair of The Road Traffic Injuries Research Network, and co-founder of The Great Outdoors, Uganda.

    Olive Kobusingye
africa-healthcare-workers

Are we pulling the right policy levers to address Africa’s shortage of healthcare workers?

Return-of-service schemes - which fund the education of health sciences students provided they return to work in their local communities for a period of time after qualifying - have been used to address healthcare worker shortages across South Africa.

But are they a good investment? A team of researchers from The George Institute and UNSW, Sydney, set out to try and answer this question by seeking the insights of key policymakers from the country’s provincial health departments. Their findings have now been published in PLOS Global Public Health.

According to lead author Sikhumbuzo Mabunda, Africa - especially sub-Saharan Africa - has the highest burden of disease in the world, the second largest population, and also the biggest shortage of health professionals.

“The country’s public health sector has only 33 medical practitioners per 100,000 people compared to the global average of 176 per 100,000 population and its primary care facilities are serviced by less than a third of the professional nurses and midwives that are actually needed,” he said.

“The main reasons driving this shortage are a limited capacity to train health professionals and the tendency for them to move to urban centres or to the private sector once qualified or even move overseas to work in more developed countries.”

But despite the adoption of several policies by governments in selected African countries in the south of the continent - like mandatory service in public sector for the duration of government-funded training - the inequitable distribution of resources persists.

To obtain on-the-ground insights into what is and isn’t working well, the George Institute research team conducted semi-structured, qualitative interviews with 16 key South African policymakers from eight of its nine provinces.

“They did feel that RoS schemes played an important role in increasing the pool of skilled health professionals and said they helped rural and disadvantaged South Africans secure academic qualifications and jobs in the health sector,” said Sikhumbuzo.

“But these benefits were undermined by lack of long-term planning, lack of transparency in the selection of some recipients, poor monitoring and coordination, and deliberate breaches of contract.”

Despite the high costs of the bursaries - reported to account for one quarter of the health worker training budget in Gauteng province, for example - no formal evaluations of the impact of RoS schemes were reported.

“We identified a number of areas where RoS schemes could be improved, such as better monitoring and enforcement of fines when contracts are broken, and policies to better support beneficiaries to fulfil their contracts,” said Sikhumbuzo.

“Given that these schemes represent a significant expenditure in an already resource constrained health system, ongoing monitoring and evaluation is important to ensure they are meeting population needs” he added.   

mental health of front line health workers

The George Institute leading the Psychosocial Support for Front Line health Workers (FLWs)

The George Institute continuing its journey in the mental health space is proud to announce another initiative supporting the psychosocial needs of the frontline workforce. The institute is leading the Psychosocial Support for Front Line health Workers (FLWs) component (in partnership with Engender Health) as a part of the USAID funded project titled - MOMENTUM Safe Surgery in Family Planning and Obstetrics and Gender-integrated Responses to COVID-19 Priorities in India, launched in Bengaluru, Karnataka on April 25, 2022.

The launch event was inaugurated and attended by Dr K Sudhakar, Hon’ble Minister for Health & Family Welfare & Medical Education, Government of Karnataka, Sri Achar Halappa Basappa, the honourable Minister for Women & Child Development & Empowerment of Differently Abled & Senior Citizens, Government of Karnataka, Dr Arundhanthi Chandrashekhar, Director, National Health Mission – Karnataka along with other senior government officials and relevant stakeholders.

The MOMENTUM project aims to prevent future and current pregnancy-related mortality and morbidity in India by promoting awareness of equitable access to high-quality care for voluntary and consented safe surgeries. It intends to provide a gender-integrated response to the emerging COVID-19 priorities in India, including for Gender-Based Violence (GBV) and psychosocial support for the FLWs.

The George Institute has been leading the mental health space for years through various flagship programmes. In this component, the team is leveraging extensive learnings and experiences from the India Health Accelerator Program and Digital health Innovations for psychosocial Support to FLWs – Accelerated response (DISHA) project. The DISHA project aims to co-create a basket of solutions (combination of online and offline) packaged as an intervention to be implemented in 25 districts across six states, namely: Assam, Chhattisgarh, Jharkhand, Karnataka, Madhya Pradesh, and Odisha. The identified interventions will respond to psychosocial issues faced by FLWs (including increasing reported incidents of stress, burnout, violence, and stigma) and build their knowledge, capacity, and resilience by promoting effective responsiveness in the future.

The hon’ble minister - Dr Sudhakar, highlighted the need for psychosocial support through digital technologies and the potential to integrate Tele-Manas programme like initiatives into the response intervention. Other partners and senior officials present at the launch event acknowledged the urgency to respond to the psychosocial needs of the FLWs and highlighted the positive impact this component holds. Collective action towards designing effective strategies can influence and strengthen the overall outcomes of the MOMENTUM project. Dr Ajay Khera, India Country Representative, Engender Health, appreciated the value of association with The George Institute and other partners to address this primary component of the project.

Following the launch event, the team undertook a preliminary field visit to the Tumkur district in Karnataka to implement the activities planned under the project. They met the District Mental Health Programme (DMHP) and visited Nagavalli Primary Health Centre (PHC) and Kuripalaya Urban PHC. They interacted with the PHC staff, Auxiliary Nurse Midwives (ANMs), Accredited Social Health Activists (ASHAs), Medical officers and DMHP team members to understand the psychosocial needs of FLWs, current coping strategies for dealing with work-related stress and interventions aimed at improving the scenario of mental health and its services provided by the DMHP team.

Moving forward, The George Institute will conduct a series of co-creation workshops in six districts to assess the FLWs’ psychosocial needs in detail and incorporate the learnings to design a final package of intervention to pilot in these six districts and then roll out in the remaining 25 Districts over next 18 months.