When does the kidney injury seen in chronic kidney disease of unknown etiology (CKDu) begin? Does subclinical kidney injury related to CKDu begin in childhood or adolescence? What are the best practices for kidney health screening in this population? We are two pediatric nephrologists who recently visited the Uddanam region in Andhra Pradesh, an area with a high prevalence of kidney diseases. Our aim was to gain deeper understand the perceptions, experiences, and attitudes of community members surrounding these questions.