The Botnar Child Road Safety Challenge (BCRSC), funded by Fondation Botnar and managed by the Global Road Safety Partnership, is a programme that aims to reduce road traffic deaths and injuries. The BCRSC is designed to address locally relevant road safety problems that affect children in small- and mid-sized cities in seven priority countries (India, Mexico, Romania, South Africa, Tunisia, Tanzania and Vietnam) with practical, innovative and evidence-based interventions. The George Institute for Global Health is conducting monitoring for the BCRSC in order to assess the impact of interventions undertaken in terms of lives saved and crashes averted, process indicators (behaviour, knowledge, attitude), as well as outputs. As part of this work, The George Institute developed a set of four guidance notes under a Botnar Child Road Safety Challenge Toolkit to assist grantees. They are published here as they may be useful to other project teams working in similar contexts and employing Knowledge Action and

The adolescent population are the future of the country and in India they contribute to the demographic dividend of the nation. Adolescence is a vulnerable period with rapid changes in physical, mental and social levels. According to World Health Organisation, around 20% of children and adolescents suffer from a disabling mental illness, and suicide is the third leading cause of death among adolescents.

Background Many health conditions are preventable if risk factors are identified early. Australian women have a high burden of modifiable risk factors including 60 percent being overweight or obese, and 20 percent having uncontrolled high blood pressure. Unfortunately there are many barriers that prevent women from visiting a health care professional and discussing their health. Hairdressers are one of the most common paid services used by Australian women, so hair salons present an opportunity to reach a large proportion of women. There is a clear need for novel approaches to engaging women on health issues, potentially including those that extend beyond traditional health care settings. Aim This study aims to understand the potential value of promoting women’s health outside traditional health care settings among female attendees at NSW hairdressing salons. Design The Hairdressers for Health study is a double-blind cluster-randomised controlled trial with a mixed-methods process evaluation.

Background Depression is a common form of mental distress that affects 1 in 7 Australians in their lifetime. People who are depressed not only feel depressed and sad, but often find they sleep poorly, experience a change in appetite, have low energy, poor concentration and have lowered self-esteem. Sometimes, they might think of harming themselves. Often, they find it hard to enjoy life or be productive. Aim This project seeks to investigate how pharmacogenomics can help to find the right antidepressant medication for people with depression. Method This is an investigator-initiated, randomised-controlled trial of pharmacogenomics-guided therapy versus standard care for people with moderate to severe depression. Study participants are randomised to either the pharmacogenomics-guided intervention arm or a standard care (control) arm. The prescribing doctors of all participants are provided with a treatment guide to inform prescription of antidepressant therapy. Potential Impact Pharmacog