Indigo is a partnership programme led by Prof Sir Graham Thornicroft from King’s College London with seven other collaborating sites in five different countries (Ethoipia, India, Tunisia, China and Nepal). The project is funded by the UK Medical Research Council (MRC). Dr Pallab K Maulik is the India site investigator who would oversee project activities at Faridabad (Haryana) site. The long term goals behind this partnership programme are to reduce the mental health treatment gap, to reduce stigma against people with mental illness, and positively modify attitudinal barriers within the primary health care, community workers, community members and mental health professionals. The overall aims of the Indigo Partnership are: to establish a strong research collaboration to provide the infrastructure for harmonised metrics and to develop stigma reduction interventions, and to carry out platform activities to strengthen the scientific understanding of mechanisms of action of stigma proc

Background Over the last few decades, the Chinese primary healthcare systemhas progressively weakened following economic liberalisation, rapid growth and changing consumer expectations. In 2009, the Chinese Government launched reforms to provide an essential public health service package’ for primary care activities, including hypertension and type 2 diabetes. Uptake of services varies and large quality gaps exist. Aims The overall goal of this five-year project is to strengthen primary health care systems to enhance uptake of the government’s essential public health services package for hypertension and type 2 diabetes in three diverse regions in China. Methods The SAPPHIRE study will be conducted in four phases, aligned with the Institute for Healthcare Improvement’s ‘Framework for Going to Full Scale’. Phase I (Understand): Rapid health system assessment to develop region- specific logic models. Phase II (Design): Develop a “change package” comprising of clin

Background Excess salt in the diet is associated with high blood pressure and increased risks of stroke, heart attack and kidney disease. This leads to serious health problems or premature death in hundreds of thousands of people in China every year. The problems with excess salt in take are particularly marked in China because food tends to be very salty. On average, Chinese people eat two and half times more salt each day than is recommended by the World Health Organization (WHO). Reducing salt in take has been clearly proven to lower blood pressure.Salt reduction is a focus for the Resolve To Save Lives (RTSL) initiative, which is commencing its salt reduction work in China.  Aims The overall goal of this five-year project is to support the implementation of the RTSL salt reduction program in China. Our work will help identify what works, what doesn’t and how to maximise impact on health with the resources available. Specifically, we will work with RTSL, the Chinese Center for

Project aims to develop an integrated, patient-centred, affordable and sustainable system for proactive management of patients undergoing peritoneal dialysis based on patients’ needs using innovative technologies and methodologies for service design Methods This is an observational cohort study which aims to develop a user-friendly and functional IT supported system for education and monitoring of patients undergoing peritoneal dialysis in their homes. We intend to collect information on physiological measures through different sensors in order to be able to compare and ascertain which methods are most acceptable to patients and providers. Study sites Postgraduate Institute of Medical Education and Research, Chandigarh and Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow. Current status The prototype Mobile Application is being tested

p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 15.0px Times; color: #323333; -webkit-text-stroke: #323333} p.p2 {margin: 0.0px 0.0px 0.0px 0.0px; font: 18.0px Arial; color: #323333; -webkit-text-stroke: #323333} span.s1 {font-kerning: none} span.s2 {text-decoration: underline ; font-kerning: none; color: #772583; -webkit-text-stroke: 0px #772583} span.s3 {font: 14.0px Calibri; font-kerning: none; color: #000000; -webkit-text-stroke: 0px #000000} span.s4 {font: 13.0px Calibri; font-kerning: none} span.s5 {font: 9.0px 'Times New Roman'; font-kerning: none} Fluid administration is a fundamental component of the management of critically ill patients and the choice of fluid is a longstanding issue of debate. Worldwide, 0.9% saline has traditionally been the most widely used resuscitation fluid, however its use is increasingly challenged by evidence that suggests its high chloride content may have clinically important adverse effects. Two pivotal George Institute trials, the Saline versus Albumin

A prospective, multicentre, parallel group, concealed, blinded, randomised controlled trial in critically ill mechanically-ventilated adults. The aim is: To determine whether the administration of placebo (daily administration of 10 ml 0.9% saline IV) is non-inferior to standard practice (daily administration of pantoprazole 40 mg IV) when judged by the incidence of clinically important gastrointestinal (GI) bleeding?  To determine whether the administration of placebo (daily administration of 10 ml 0.9% saline IV) is superior to standard practice (daily administration of pantoprazole 40 mg IV) as it results in a reduction in net harm by reducing the incidence of serious infectious complications (ventilator-associated pneumonia and Clostridium difficile infection) and therefore "downstream" harms when measured as duration of mechanical ventilation, intensive care unit (ICU) and hospital length of stay, and 90-day mortality? 

Current status– finished recruitment – in follow-up.TRIDENT is an international medical research study which aims to determine the effect of more intensive blood pressure control to prevent recurrent stroke in patients who have had an intracerebral haemorrhage (ICH) (a stroke caused by ruptured blood vessel in the brain). The aim of this project is to test the superiority of a fixed low-dose combination blood pressure-lowering pill (Triple Pill) strategy in recurrent stroke in patients with a history of ICH.Acute ICH accounts for at least 10% of the 20 million new strokes in the world each year. ICH survivors are at high risk of recurrent stroke and other serious cardiovascular events. Numerous studies have proven the benefit of stroke survivors reducing their risk of recurrent stroke through taking blood pressure-lowering medications. However, studies have shown that many ICH survivors are either not receiving any blood pressure-lowering medication or they are receiving inadequate control.The TRIDENT stu

Chronic kidney disease (CKD) has become a growing public health problem worldwide with a serious socio-economic impact. CKD results in mortality due to progression to end-stage renal disease and a disproportionate increase in the risk of cardiovascular disease (CVD) and associated deaths. Recent advances suggest the possibility of using biologically relevant biomarkers to develop prediction algorithms for outcomes in patients with CKD. However, there are no large longitudinal studies comparing the differences in racially, geographically and genetically different populations. Aim: Project aims to establish a large cohort of Indian patients with moderate kidney failure (40-60% reduction in kidney function) by enrolling 5000 patients cared for at 8 centers nationwide, who will be prospectively followed for a minimum of five years and to develop prediction algorithms. It will be the first study to evaluate the prediction power of biologically important biomarkers on clinically relevant end

Healthcare associated infections (HAI) cause significant and life-threatening harm to patients and incur major additional costs. Patients with kidney disease are especially susceptible to HAI, due to the harm associated with central dialysis catheter use. These catheters, essential to the delivery of life-sustaining dialysis treatment, are widely used and are a major driver of bloodstream infection and increased mortality seen in patients receiving dialysis. The REDUCCTION Partnership Project has the following aims: To define the national, clinical and economic burden of dialysis catheter infections in Australia and New Zealand To implement an evidence-based and systematic intervention package using a stepped-wedge cluster design with the objective of reducing dialysis catheter-related bacteraemia. To establish a framework for monitoring dialysis catheter-related bacteraemia and sustaining improvements from the intervention phase. Current status: Data collection for our primary analysis i