@article{16567,
  author = {Cass Alan and White S. and Dunstan D. and Chadban S. and Polkinghorne K. and Atkins R.},
  title = {Physical inactivity and chronic kidney disease in Australian adults: the AusDiab study},
  abstract = {<p>
BACKGROUND AND AIMS: Physical inactivity is associated with cardiovascular risk however its relationship to chronic kidney disease is largely unknown. We examined the association between leisure-time physical activity and risk of chronic kidney disease in a prospective, population-based cohort of Australians aged &gt;/= 25 years (AusDiab). METHODS AND RESULTS: The baseline sample included 10,966 adults (4951 males and 6015 females). From this sample, 6318 participants with complete baseline and 5-year follow-up urinalysis and serum creatinine measurements formed the study population for longitudinal analysis. Self-reported leisure-time physical activity was measured using a validated, interviewer-administered questionnaire. Compared with sufficiently active individuals (&gt;/= 150 min physical activity per week), those who were inactive (0 min/week) were more likely to have albuminuria at baseline (multivariate-adjusted OR=1.34, 95% CI 1.10-1.63). Inactivity (versus sufficient physical activity) was associated with increased age- and sex-adjusted odds of an estimated glomerular filtration rate &lt;3rd percentile (OR=1.30, 95% CI 1.02-1.65), although this was not significant after multivariate adjustment (OR=1.17, 95% CI 0.91-1.50). Obese, inactive individuals were significantly more likely to have albuminuria at baseline (multivariate-adjusted OR=1.74, 95% CI 1.35-2.25), compared with sufficiently active, non-obese individuals. Baseline physical activity status was not significantly associated with longitudinal outcomes. CONCLUSIONS: Physical inactivity is cross-sectionally associated with albuminuria prevalence, particularly when combined with obesity. Future studies are needed to determine whether this association is causal and the importance of physical activity in CKD prevention.
</p>
},
  year = {2011},
  journal = {Nutrition, Metabolism and Cardiovascular Diseases},
  volume = {21},
  edition = {2009/11/27},
  number = {2},
  pages = {104-12},
  isbn = {1590-3729 (Electronic)0939-4753 (Linking)},
  note = {White, Sarah LDunstan, David WPolkinghorne, Kevan RAtkins, Robert CCass, AlanChadban, Steven JResearch Support, Non-U.S. Gov'tGermanyNutrition, metabolism, and cardiovascular diseases : NMCDNutr Metab Cardiovasc Dis. 2011 Feb;21(2):104-12. Epub 2009 Nov 25.},
  language = {eng},
}