@article{21596,
  author = {Anderson Craig and Carcel C.},
  title = {Timing of blood pressure lowering in acute ischemic stroke},
  abstract = {<p>
Whether there are any benefits without harm from early lowering of blood pressure (BP) in the setting of acute ischemic stroke (AIS) has been a longstanding controversy in medicine. Whilst most studies have consistently shown associations between elevated BP, particularly systolic BP, and poor outcome, some also report that very low BP (systolic &lt;130 mmHg) and large reductions in systolic BP are associated with poor outcomes in AIS. However, despite these associations, the observed U- or J-shaped relationship between BP and outcome in these patients may not be causally related. Patients with more severe strokes may have a more prominent autonomic response and later lower BP as their condition worsens, often pre-terminally. Fortunately, substantial progress has been made in recent years with new evidence arising from well-conducted randomized trials. This review outlines new evidence and recommendations for clinical practice over BP management in AIS.
</p>
},
  year = {2015},
  journal = {Current Atherosclerosis Reports},
  volume = {17},
  edition = {2015/06/05},
  number = {8},
  pages = {520},
  isbn = {1534-6242 (Electronic)<br/>1523-3804 (Linking)},
  note = {Carcel, Cheryl<br/>Anderson, Craig S<br/>United States<br/>Curr Atheroscler Rep. 2015 Aug;17(8):520. doi: 10.1007/s11883-015-0520-y.},
  language = {eng},
}