@article{23184,
  author = {Kumar Vinod and Sakhuja Vinay and Ramachandran Raja and Jha V. and Kumar Vivek and Yadav Ashok and Nada Ritambhra and Rathi Manish and Pinnamaneni Venkata and Ghosh Ratan and Kohli Harbir and Gupta Krishan},
  title = {Two-Year Follow-up Study of Membranous Nephropathy Treated With Tacrolimus and Corticosteroids Versus Cyclical Corticosteroids and Cyclophosphamide.},
  abstract = {<p>
<b>Introduction: </b>Both cCTX/GCs and CNIs are recommended as first-line agents in the management of PMN. The present study is an extended report of patients randomized to receive TAC/GCs or cCTX/GCs at 2 years post randomization.
</p>

<p>
<b>Methods: </b>Seventy patients enrolled in the clinical trial Tacrolimus Combined With Corticosteroids Versus Modified Ponticelli Regimen in Treatment of Idiopathic Membranous Nephropathy: Randomized Control Trial were followed quarterly between 12 and 24 months. At the end of 24 months, 3 patients were lost to follow-up.
</p>

<p>
<b>Results: </b>At 18 months, 66% and 89% (P&nbsp;= 0.04) were in remission in TAC/GCs and cCTX/GCs groups, respectively. At 18 and 24 months, 60% and 86% (P&nbsp;= 0.03) of cases were in remission in the TAC/GCs and cCTX/GCs groups, respectively. At 18 months, 57% and 83% (P&nbsp;= 0.03) of the patients in TAC/GCs and cCTX/GCs groups were in remission without need of any additional immunosuppression (persistent remission) and, at 24 months, 43% and 80% (P&nbsp;= 0.002) were in persistent remission in TAC/GCs and cCTX/GCs groups, respectively. Relapse rate after any remission was 40% and 6.7% in TAC/GCs and cCTX/GCs groups, respectively (P&nbsp;= 0.007). There was an association of aPLA2R titers with remission or resistance (P&nbsp;= 0.006) in relapsing PMN. The significant decrease in eGFR after 12 months of TAC/GCs therapy normalized at 18 and 24 months.
</p>

<p>
<b>Discussion: </b>At 2 years after randomization, relapse rates are higher for TAC/GCs compared with cCTX/GCs in PMN patients. Thus, cCTX/GCs are better than TAC/GCs in the longer term in PMN patients.
</p>
},
  year = {2017},
  journal = {Kidney Int Rep},
  volume = {2},
  pages = {610-616},
  issn = {2468-0249},
  doi = {10.1016/j.ekir.2017.02.004},
  language = {eng},
}