02383nas a2200253   4500000000100000008004100001100001500042700002200057700001800079700001800097700002200115700001700137700001800154700001900172700001500191700001500206700001600221245010600237250001500343300001200358490000700370520170600377020004602083       2012                            d1 aGrobbee D.1 avan der Schouw Y.1 aCzernichow S.1 avan Dieren S.1 ade Galan Bastiaan1 aKengne Andre1 aWoodward Mark1 aZoungas Sophia1 aPoulter N.1 aBeulens J.1 aChalmers J.00aWeight changes and their predictors amongst 11 140 patients with type 2 diabetes in the ADVANCE trial  a2012/01/10  a464-4690 v143 a<p>
Aims: To determine the baseline characteristics and glucose-lowering therapies associated with weight change among patients with type 2 diabetes. Methods: Eleven thousand one hundred and forty participants in the ADVANCE trial were randomly assigned to an intensive [aiming for a haemoglobin A1c (HbA1c) <!--=6.5%] or a standard blood glucose-control strategy. Weight was measured at baseline and every 6 months over a median follow-up of 5 years. Multivariable linear regression and linear-mixed effect models were used to examine predictors of weight change. Results: The mean difference in weight between the intensive and standard glucose-control arm during follow-up was 0.75 kg (95% CI: 0.56-0.94), p-value <0.001. The mean weight decreased by 0.70 kg (95% CI: 0.53-0.87), p < 0.001 by the end of follow-up in the standard arm but remained stable in the intensive arm, with a non-significant gain of 0.16 kg (95% CI: -0.02 to 0.34), p = 0.075. Baseline factors associated with weight gain were younger age, higher HbA1c, Caucasian ethnicity and number of glucose-lowering medications. Treatment combinations including insulin [3.22 kg (95% CI: 2.92-3.52)] and thiazolidinediones [3.06 kg (95% CI: 2.69-3.43)] were associated with the greatest weight gain while treatment combinations including sulphonylureas were associated with less weight gain [0.71 kg (95%CI: 0.39-1.03)]. Conclusions: Intensive glucose-control regimens are not necessarily associated with substantial weight gain. Patient characteristic associated with weight change were age, ethnicity, smoking and HbA1c. The main treatment strategies predicting weight gain were the use of insulin and thiazolidinediones.-->
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