02017nas a2200181   4500000000100000008004100001100001600042700001300058700001600071700001200087700001500099245020000114250001500314300000800329490000600337520144600343020004601789       2010                            d1 aThompson H.1 aPell ACh1 aAnderson J.1 aPell J.1 aChow Clara00aScreening families of patients with premature coronary heart disease to identify avoidable cardiovascular risk: a cross-sectional study of family members and a general population comparison group  a2010/05/13  a1320 v33 a<p>
ABSTRACT: BACKGROUND: Primary prevention should be targeted at individuals with high global cardiovascular risk, but research is lacking on how best to identify such individuals in the general population. Family history is a good proxy measure of global risk and may provide an efficient mechanism for identifying high risk individuals. The aim was to test the feasibility of using patients with premature cardiovascular disease to recruit family members as a means of identifying and screening high-risk individuals. FINDINGS: We recruited family members of 50 patients attending a cardiology clinic for premature coronary heart disease (CHD). We compared their cardiovascular risk with a general population control group, and determined their perception of their risk and current level of screening. 103 (36%) family members attended screening (27 siblings, 48 adult offspring and 28 partners). Five (5%) had prevalent CHD. A significantly higher percentage had an ASSIGN risk score &gt;20% compared with the general population (13% versus 2%, p &lt; 0.001). Only 37% of family members were aware they were at increased risk and only 50% had had their blood pressure and serum cholesterol level checked in the previous three years. CONCLUSIONS: Patients attending hospital for premature CHD provide a mechanism to contact family members and this can identify individuals with a high global risk who are not currently screened.
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