01989nas a2200205   4500000000100000008004100001260001600042653002400058653001200082100001400094700001600108700001700124700002200141700001800163245014400181300002800325490000600353050000600359520141800365       2006                            d  c5446336600110aPeer Reviewed Paper10aChecked1 aCurtin J.1 aHerbert Rob1 aLatimer Jane1 aBroderick Carolyn1 aSelvadurai H.00aThe effect of an exercise intervention on aerobic fitness, strength and quality of life in children with haemophilia (ACTRN012605000224628)  aEpub. [Impact Factor 0]0 v6  aN3 a<p>
BACKGROUND : Children with haemophilia have lower levels of fitness and strength than their healthy peers. We present the protocol of a study designed to determine whether an exercise intervention improves quality of life, aerobic fitness and strength in children with haemophilia. METHODS/DESIGN : The study will be a randomised, assessor-blinded, controlled trial of exercise treatment. Seventy children aged between 6 and 18 years with haemophilia or von Willebrand disease will be recruited from two paediatric haemophilia clinics in NSW. Each participant will be allocated to an exercise group or a control group using a concealed allocation procedure. The control group will receive usual medical care while the intervention group will receive usual medical care plus an exercise program for 12 weeks. Outcomes (VO2peak, knee extensor strength and quality of life) will be measured at baseline and on completion of the exercise program by a blinded assessor. The primary analysis will be conducted on an intention to treat basis. The effects of the exercise intervention on each of the three primary outcomes will be estimated from between-group differences in the mean outcome adjusted for baseline scores. DISCUSSION : This study will be the first randomised controlled trial to examine the effects of a structured exercise program on fitness and quality of life in children with haemophilia.
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