02267nas a2200289   4500000000100000008004100001100001400042700001300056700001600069700001200085700001200097700001600109700001800125700001300143700001600156700001900172700001300191700001500204700001500219700001600234245008100250250001500331300001100346490000700357520156200364020005101926       2014                            d1 aHeeley E.1 aStapf C.1 aRobinson T.1 aWang J.1 aWang X.1 aHirakawa Y.1 aWoodward Mark1 aArima H.1 aDelcourt C.1 aAnderson Craig1 aHuang Y.1 aLavados P.1 aParsons M.1 aChalmers J.00aOptimal achieved blood pressure in acute intracerebral hemorrhage: INTERACT2  a2015/01/02  a464-710 v843 a<p>
OBJECTIVES: To investigate the effects of intensive blood pressure (BP) lowering according to baseline BP levels and optimal achieved BP levels in patients with acute intracerebral hemorrhage (ICH). METHODS: INTERACT2 was an open, blinded endpoint, randomized controlled trial in 2,839 patients with ICH within 6 hours of onset and elevated systolic BP (SBP) (150-220 mm Hg) who were allocated to receive intensive (target SBP &lt;140 mm Hg within 1 hour, with lower limit of 130 mm Hg for treatment cessation) or guideline-recommended (target SBP &lt;180 mm Hg) BP-lowering treatment. Outcome was physical function across all 7 levels of the modified Rankin Scale at 90 days. RESULTS: Analysis of the randomized comparisons showed that intensive BP lowering produced comparable benefits on physical function at 90 days in 5 subgroups defined by baseline SBP of &lt;160, 160-169, 170-179, 180-189, and &gt;/=190 mm Hg (p homogeneity = 0.790). Analyses of achieved BP showed linear increases in the risk of physical dysfunction for achieved SBP above 130 mm Hg for both hyperacute (1-24 hours) and acute (2-7 days) phases while modest increases were also observed for achieved SBP below 130 mm Hg. CONCLUSIONS: Intensive BP lowering appears beneficial across a wide range of baseline SBP levels, and target SBP level of 130-139 mm Hg is likely to provide maximum benefit in acute ICH. CLASSIFICATION OF EVIDENCE: This study provides Class I evidence that the effect of intensive BP lowering on physical function is not influenced by baseline BP.
</p>
  a1526-632X (Electronic)<br/>0028-3878 (Linking)