01356nas a2200217   4500000000100000008004100001100001400042700002600056700001800082700001900100700001600119700002400135700001900159700001800178700001800196700002200214700001800236245006500254520080500319022001401124       2017                            d1 aMyburgh J1 aTimsit Jean-François1 aPerner Anders1 aGordon Anthony1 aAngus Derek1 aLamontagne Francois1 aMachado Flavia1 aRussell James1 aMarshall John1 aShankar-Hari Manu1 aSinger Mervyn00aThe intensive care medicine research agenda on septic shock.3 a<p>
Septic shock remains a global health challenge with millions of cases every year, high rates of mortality and morbidity, impaired quality of life among survivors and relatives, and high resource use both in developed and developing nations. Care and outcomes are improving through organisational initiatives and updated clinical practice guidelines based on clinical research mainly carried out by large collaborative networks. This progress is likely to continue through the collaborative work of the established and merging trials groups in many parts of the world and through refined trial methodology and translational work. In this review, international experts summarize the current position of clinical research in septic shock and propose a research agenda to advance this field.
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