02413nas a2200193   4500000000100000008004100001100001200042700001800054700001600072700002000088700001800108700001600126700001600142245012200158300001400280490000700294520190400301022001402205       2017                            d1 aLi Ming1 aClarke Philip1 aHua Xinyang1 aMcDermott Robyn1 aWenitong Mark1 aTran-Duy An1 aLung Thomas00aValidation and recalibration of the Framingham cardiovascular disease risk models in an Australian Indigenous cohort.  a1660-16690 v243 a<p>Background In Australia, clinical guidelines for primary prevention of cardiovascular disease recommend the use of the Framingham model to help identify those at high risk of developing the disease. However, this model has not been validated for the Indigenous population. Design Cohort study. Methods Framingham models were applied to the Well Person's Health Check (WPHC) cohort (followed 1998-2014), which included 1448 Aboriginal and Torres Strait Islanders from remote Indigenous communities in Far North Queensland. Cardiovascular disease risk predicted by the original and recalibrated Framingham models were compared with the observed risk in the WPHC cohort. Results The observed five- and 10-year cardiovascular disease probability of the WPHC cohort was 10.0% (95% confidence interval (CI): 8.5-11.7) and 18.7% (95% CI: 16.7-21.0), respectively. The Framingham models significantly underestimated the cardiovascular disease risk for this cohort by around one-third, with a five-year cardiovascular disease risk estimate of 6.8% (95% CI: 6.4-7.2) and 10-year risk estimates of 12.0% (95% CI: 11.4-12.6) and 14.2% (95% CI: 13.5-14.8). The original Framingham models showed good discrimination ability (C-statistic of 0.67) but a significant lack of calibration (χbetween 82.56 and 134.67). After recalibration the 2008 Framingham model corrected the underestimation and improved the calibration for five-year risk prediction (χof 18.48). Conclusions The original Framingham models significantly underestimate the absolute cardiovascular disease risk for this Australian Indigenous population. The recalibrated 2008 Framingham model shows good performance on predicting five-year cardiovascular disease risk in this population and was used to calculate the first risk chart based on empirical validation using long-term follow-up data from a remote Australian Indigenous population.</p>  a2047-4881