02458nas a2200421   4500000000100000008004100001653001000042653001100052653001100063653000900074653001600083653002800099653001500127653003300142653002400175653002300199653002600222653001800248653002400266653002300290653001700313653001400330653001300344100001600357700001100373700001600384700001600400700001800416700001900434700001500453700002100468700002200489245008100511300001400592490000700606520140900613022001402022       2017                            d10aAdult10aFemale10aHumans10aMale10aMiddle Aged10aCardiovascular Diseases10abiomarkers10aRenal Insufficiency, Chronic10aDietary Supplements10aC-Reactive Protein10aEndothelium, Vascular10aInterleukin-610aPulse Wave Analysis10aVascular Stiffness10aVasodilation10aVitamin D10aVitamins1 aKumar Vinod1 aJha V.1 aKumar Vivek1 aYadav Ashok1 aGupta Krishan1 aBillot Laurent1 aLal Anupam1 aSinghal Manphool1 aBanerjee Debasish00aA Randomized Trial of Vitamin D Supplementation on Vascular Function in CKD.  a3100-31080 v283 a<p>Vitamin D deficiency associates with mortality in patients with CKD, and vitamin D supplementation might mitigate cardiovascular disease risk in CKD. In this randomized, double-blind, placebo-controlled trial, we investigated the effect of cholecalciferol supplementation on vascular function in 120 patients of either sex, aged 18-70 years, with nondiabetic CKD stage 3-4 and vitamin D deficiency (serum 25-hydroxyvitamin D ≤20 ng/ml). We randomized patients using a 1:1 ratio to receive either two directly observed oral doses of cholecalciferol (300,000 IU) or matching placebo at baseline and 8 weeks. The primary outcome was change in endothelium-dependent brachial artery flow-mediated dilation at 16 weeks. Secondary outcome measures included changes in pulse wave velocity and circulating biomarkers. Cholecalciferol supplementation significantly increased endothelium-dependent brachial artery flow-mediated dilation at 16 weeks, whereas placebo did not (between-group difference in mean change: 5.49%; 95% confidence interval, 4.34% to 6.64%;<0.001). Intervention also led to significant favorable changes in pulse wave velocity and circulating IL-6 levels. Thus, in nondiabetic patients with stage 3-4 CKD and vitamin D deficiency, vitamin D supplementation may improve vascular function. This study is registered with the Clinical Trials Registry of India (no.: CTRI/2013/05/003648).</p>  a1533-3450