02664nas a2200397   4500000000100000008004100001653001100042653001100053653000900064653000900073653001600082653002400098653001700122653002400139653001500163653001900178653002500197100001400222700001400236700001600250700001600266700001900282700001300301700001700314700001600331700001300347700001300360700002000373700001800393700001900411245014500430300001000575490000700585520166000592022001402252       2017                            d10aFemale10aHumans10aAged10aMale10aMiddle Aged10aProspective Studies10aTime Factors10aAcute Kidney Injury10aCreatinine10aContrast Media10aCoronary Angiography1 aWang Ying1 aXian Ying1 aLi Hua-Long1 aBei Wei-Jie1 aGuo Xiao-Sheng1 aWang Kun1 aChen Shi-Qun1 aChen Ji-Yan1 aLiu Yong1 aTan Ning1 aDuan Chong-Yang1 aChen Ping-Yan1 aGeng Qing-Shan00aCould late measurement of serum creatinine be missed for patients without early increase in serum creatinine following coronary angiography?  ae84600 v963 a<p>Most patients are discharged early (within 24 hours) after coronary angiography (CAG) and may miss identification the late (24-48 hours) increase in serum creatinine (SCr), whose characteristics and prognosis have been less intensively investigated.We prospectively recruited 3065 consecutive patients with SCr measurement, including only1344 patients with twice SCr measurement (both early and late). The late contrast-induced acute kidney injury (CI-AKI) was defined as significantly increase in SCr (≥0.3 mg/dL or ≥50%) not in early phase, but only in late phase after the procedure, and the early CI-AKI experienced a significantly increase in early phase.Overall, CI-AKI developed in 134 patients (10%), and the incidence of late and early CI-AKI were 3.6% and 6.4%, respectively. There were no difference in age, renal, and heart function, contrast volume among patients with late and early CI-AKI. With mean follow-up period of 2.45 years, long-term mortality (3 years, 29.7% and 35.6%, respectively, P = .553) was similar for patients with late and early CI-AKI. Cox analysis showed that both late (adjusted HR 2.05; 95% CI, 1.02-4.15) and early (adjusted HR 2.68; 95% CI, 1.57-4.59) CI-AKI was significantly associated with long-term mortality (all P < .001).Only late increase in SCr, as late CI-AKI, accounted for about one-third of CI-AKI incidence and has similar good predictive value for long-term mortality with that of an early increase, early CI-AKI, among patients with SCr measured twice, supporting the importance of late repeating SCr measurement after CAG, even without an early significant increase in SCr.</p>  a1536-5964