03012nas a2200349 4500000000100000008004100001260001600042653001100058653001800069653002600087653001200113653002000125653002900145653003500174653002600209653002000235100002200255700001800277700002000295700001700315700001400332700001800346700002000364700002000384700001800404700001700422245011300439300001200552490000700564520207700571022001402648 2018 d c5146547146010aHumans10aLow back pain10aEpidemiologic Studies10aPosture10aLower Extremity10aMusculoskeletal Diseases10aObservational Studies as Topic10aOccupational Diseases10aUpper Extremity1 aMaher Christopher1 aCoenen Pieter1 aWillenberg Lisa1 aParry Sharon1 aShi Joyce1 aRomero Lorena1 aBlackwood Diana1 aHealy Genevieve1 aDunstan David1 aStraker Leon00aAssociations of occupational standing with musculoskeletal symptoms: a systematic review with meta-analysis. a176-1830 v523 a

OBJECTIVE: Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms.

DESIGN: A systematic review was performed. Data from included articles were extracted and described, and meta-analyses conducted when data were sufficiently homogeneous.

DATA SOURCES: Electronic databases were systematically searched.

ELIGIBILITY CRITERIA: Peer-reviewed articles on occupational standing and musculoskeletal symptoms from epidemiological studies were identified.

RESULTS: Of the 11 750 articles screened, 50 articles reporting 49 studies were included (45 cross-sectional and 5 longitudinal; n=88 158 participants) describing the associations of occupational standing with musculoskeletal symptoms, including low-back (39 articles), lower extremity (14 articles) and upper extremity (18 articles) symptoms. In the meta-analysis, 'substantial' (>4 hours/workday) occupational standing was associated with the occurrence of low-back symptoms (pooled OR (95% CI) 1.31 (1.10 to 1.56)). Evidence on lower and upper extremity symptoms was too heterogeneous for meta-analyses. The majority of included studies reported statistically significant detrimental associations of occupational standing with lower extremity, but not with upper extremity symptoms.

CONCLUSIONS: The evidence suggests that substantial occupational standing is associated with the occurrence of low-back and (inconclusively) lower extremity symptoms, but there may not be such an association with upper extremity symptoms. However, these conclusions are tentative as only limited evidence was found from high-quality, longitudinal studies with fully adjusted models using objective measures of standing.

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