01854nas a2200193   4500000000100000008004100001100002500042700002300067700001600090700002500106700002600131700002100157700002100178700002700199700002300226245010200249520129500351022001401646       2017                            d1 aTrongtrakul Konlawij1 aSawawiboon Chaiwut1 aWang Amanda1 aChitsomkasem Anusang1 aLimphunudom Ploynapas1 aKurathong Sathit1 aPrommoon Surasee1 aTrakarnvanich Thananda1 aSrisawat Nattachai00aAcute Kidney Injury in Critically Ill Surgical Patients: Epidemiology, Risk Factors and Outcomes.3 a<p><b>AIM: </b>Acute kidney injury (AKI) is one of the most serious complications seen in intensive care units (ICUs). However, its epidemiology, risk factors and clinical outcomes in surgical critically ill patients remains unclear.</p><p><b>METHODS: </b>A prospective cohort study was conducted in surgical intensive care unit (ICU) of the university hospital in Bangkok, Thailand. AKI was diagnosed according to the KDIGO 2012 criteria.</p><p><b>RESULTS: </b>A total of 189 of the 400 patients enrolled in our study developed AKI (47.3%). The severity was: stage 1 = 29.6% of all AKI (56 cases), stage 2 = 30.7% (58 cases), and stage 3 = 39.7% (75 cases). Risk factors of AKI development included a higher BMI, a greater APACHE-II score, septic shock, use of mechanical ventilation, acute medical complications during surgical admission, and pre-existing chronic kidney disease. After adjustment for covariates, only the most severe stage of AKI (stage 3) was associated with increasing 28-day ICU mortality compared with no AKI stage, HR=7.75 (95% CI, 1.46-41.20, P=0.02).</p><p><b>CONCLUSIONS: </b>AKI is common and is associated with an increase in mortality in surgical ICU patients. There should be more focus on patients with AKI risk factors to prevent this deleterious event.</p>  a1440-1797