OBJECTIVE: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. METHODS: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. RESULTS: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98). CONCLUSIONS: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
AD - The George Institute for Global Health, University of Sydney, Sydney, Australia. AN - 22056629 BT - Preventive Medicine ET - 2011/11/08 LA - eng M1 - 1 N1 - Murakami, YoshitakaHuxley, Rachel RLam, Tai-HingTsukinoki, RumiFang, XianghuaKim, Hyeon ChangWoodward, MarkAsia Pacific Cohort Studies CollaborationResearch Support, Non-U.S. Gov'tUnited StatesPreventive medicinePrev Med. 2012 Jan 1;54(1):38-41. Epub 2011 Oct 28. N2 -OBJECTIVE: To examine the effects of diabetes on coronary heart disease, ischemic and hemorrhagic stroke and cardiovascular disease according to category of body mass index. METHODS: Data on 161,161 men and women from 31 cohorts (baseline years, 1966-99; mean follow-up, 2-24 years) from the Asia Pacific Cohort Studies Collaboration were analyzed using Cox regression, stratified by sex and study and adjusted for age, systolic blood pressure and smoking. Diabetes was self-reported in all but one study. Body mass index was divided into five categories according to the World Health Organization Asian criteria. RESULTS: The hazard ratio (diabetes v. not) for cardiovascular disease was 1.83 (95% confidence interval, 1.66-2.01). Across body mass index categories, this hazard ratio did not change significantly (p=0.19). Similar lack of difference across body mass index groups was found for coronary heart disease (p=0.33), ischemic stroke (p=0.97) and hemorrhagic stroke (p=0.98). CONCLUSIONS: Body mass index does not modify the effect of diabetes on major cardiovascular outcomes.
PY - 2012 SN - 1096-0260 (Electronic)0091-7435 (Linking) SP - 38 EP - 41 T2 - Preventive Medicine TI - Diabetes, body mass index and the excess risk of coronary heart disease, ischemic and hemorrhagic stroke in the Asia Pacific Cohort Studies Collaboration VL - 54 ER -